中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2012年
5期
359-360
,共2页
郭英军%王雅坤%王凯波%金光玉%赵玉铭
郭英軍%王雅坤%王凱波%金光玉%趙玉銘
곽영군%왕아곤%왕개파%금광옥%조옥명
目的 探讨继发性瘢痕疙瘩皮损中表皮朗格汉斯细胞(LC)和真皮CD68阳性组织细胞的分布和密度.方法 取30例继发性瘢痕疙瘩患者的皮损、14例正常人皮肤组织切片进行CD1a和CD68免疫组化染色.以测微尺标定目镜方格计数方格内阳性细胞数,计算出单位面积内细胞的密度.组间比较采用SPSS软件进行Studentt检验.结果 在继发性瘢痕疙瘩表皮内CD1a阳性LC密度为(61±49)个/mm2,正常表皮为(258±61)个/mm2,两组比较,t=9.88,P< 0.01;继发性瘢痕疙瘩真皮CD1a阳性细胞密度为(40±65)个/mm2.继发性瘢痕疙瘩表皮中无CD68阳性细胞,真皮内CD68阳性组织细胞密度为(287±73)/mm2,正常皮肤为(290±22)个/mm2,两组比较,t=0.02,P>0.05.继发性瘢痕疙瘩真皮浅层CD68阳性组织细胞占真皮中所有细胞的62%±12%,而正常皮肤为70%±14%,两组比较,t=2.66,P<0.05.结论 继发性瘢痕疙瘩表皮中LC减少,无CD68阳性的细胞.真皮中LC增多;真皮浅层CD68阳性组织细胞占真皮中所有细胞的比例下降.
目的 探討繼髮性瘢痕疙瘩皮損中錶皮朗格漢斯細胞(LC)和真皮CD68暘性組織細胞的分佈和密度.方法 取30例繼髮性瘢痕疙瘩患者的皮損、14例正常人皮膚組織切片進行CD1a和CD68免疫組化染色.以測微呎標定目鏡方格計數方格內暘性細胞數,計算齣單位麵積內細胞的密度.組間比較採用SPSS軟件進行Studentt檢驗.結果 在繼髮性瘢痕疙瘩錶皮內CD1a暘性LC密度為(61±49)箇/mm2,正常錶皮為(258±61)箇/mm2,兩組比較,t=9.88,P< 0.01;繼髮性瘢痕疙瘩真皮CD1a暘性細胞密度為(40±65)箇/mm2.繼髮性瘢痕疙瘩錶皮中無CD68暘性細胞,真皮內CD68暘性組織細胞密度為(287±73)/mm2,正常皮膚為(290±22)箇/mm2,兩組比較,t=0.02,P>0.05.繼髮性瘢痕疙瘩真皮淺層CD68暘性組織細胞佔真皮中所有細胞的62%±12%,而正常皮膚為70%±14%,兩組比較,t=2.66,P<0.05.結論 繼髮性瘢痕疙瘩錶皮中LC減少,無CD68暘性的細胞.真皮中LC增多;真皮淺層CD68暘性組織細胞佔真皮中所有細胞的比例下降.
목적 탐토계발성반흔흘탑피손중표피랑격한사세포(LC)화진피CD68양성조직세포적분포화밀도.방법 취30례계발성반흔흘탑환자적피손、14례정상인피부조직절편진행CD1a화CD68면역조화염색.이측미척표정목경방격계수방격내양성세포수,계산출단위면적내세포적밀도.조간비교채용SPSS연건진행Studentt검험.결과 재계발성반흔흘탑표피내CD1a양성LC밀도위(61±49)개/mm2,정상표피위(258±61)개/mm2,량조비교,t=9.88,P< 0.01;계발성반흔흘탑진피CD1a양성세포밀도위(40±65)개/mm2.계발성반흔흘탑표피중무CD68양성세포,진피내CD68양성조직세포밀도위(287±73)/mm2,정상피부위(290±22)개/mm2,량조비교,t=0.02,P>0.05.계발성반흔흘탑진피천층CD68양성조직세포점진피중소유세포적62%±12%,이정상피부위70%±14%,량조비교,t=2.66,P<0.05.결론 계발성반흔흘탑표피중LC감소,무CD68양성적세포.진피중LC증다;진피천층CD68양성조직세포점진피중소유세포적비례하강.
Objective To analyze the distribution and density of Langerhans cells and dermal CD68 positive histiocytes in lesions of secondary keloid.Methods Tissue specimens were resected from the lesions of 30 patients with secondary keloid and normal skin of 14 human controls.Immunohistochemistry was performed to observe the expressions of CD68 and CD1a in these specimens.A micrometer was used to count the number of positively stained cells per unit area.The Student's t test was conducted for data analysis by using the SPSS software.Results The density of CD1a+ Langerhans cells was (61 ± 49) cells/mm2 in the epidermis of secondary keloid lesions, (258 ± 61 ) cells/mm2 in the control epidermis,and (40 ± 65) cells/mm2 in the dermis of keloid lesions.CD68+ cells were absent in the epidermis of keloid lesions.Significant differences were observed in the density of CD1a+ Langerhans cells between the lesional and normal control epidermis (t =9.88,P < 0.001 ) and in the percentage of CD68+ cells in nucleated cells between the superficial dermis of lesions and control skin(62% ± 12% vs.70% ± 14%,t =2.66,P < 0.05).The density of dermal CD68+ histiocytes was similar between the lesions and control skin ((287 ± 73) cells/mm2 vs.(290 ± 22) cell/mm2,t =0.02,P > 0.05).Conclusions In keloid lesions,Langerhans cells decrease in the epidermis but increase in the dermis,CD68+ histiocytes are absent in the epidermis,and reduced in the dermis with a declined percentage in nucleated cells.