CAJ | 학술논문

目的探讨血清硫酸粘多糖片段(SGF)、恶性肿瘤相关物质(TSGF)及癌胚抗原(CEA)三种肿瘤标志物在非小细胞肺癌(NSCLC)患者血清中的表达及临床意义.方法采用胶乳凝集法、生化显色法和化学发光法检测50例NSCLC患者血清SGF、TSGF及CEA水平,比较不同的检测组合方式在NSCLC诊断中的价值.结果 NSCLC Ⅰ～Ⅱ期与Ⅲ期间及Ⅲ期与Ⅳ期间SGF水平差异有统计学意义(P<0.05);SGF、TS-GF及CEA单项与SGF和TSGF组合检测特异性差异无统计学意义(P>0.05);SGF和TSGF组合与SGF、TS-GF及CEA组合间灵敏度差异无统计学意义(P>0.05),其特异性差异有统计学意义(P<0.05).结论三种肿瘤标志物在NSCLC患者血清中均有较高表达,不同的组合检测中SGF与TSGF组合对NSCLC诊断优于其他组合.
목적 탐토혈청류산점다당편단(SGF)、악성종류상관물질(TSGF)급암배항원(CEA)삼충종류표지물재비소세포폐암(NSCLC)환자혈청중적표체급림상의의.방법 채용효유응집법、생화현색법화화학발광법검측50례NSCLC환자혈청SGF、TSGF급CEA수평,비교불동적검측조합방식재NSCLC진단중적개치.결과 NSCLC Ⅰ～Ⅱ기여Ⅲ기간급Ⅲ기여Ⅳ기간SGF수평차이유통계학의의(P<0.05);SGF、TS-GF급CEA단항여SGF화TSGF조합검측특이성차이무통계학의의(P>0.05);SGF화TSGF조합여SGF、TS-GF급CEA조합간령민도차이무통계학의의(P>0.05),기특이성차이유통계학의의(P<0.05).결론 삼충종류표지물재NSCLC환자혈청중균유교고표체,불동적조합검측중SGF여TSGF조합대NSCLC진단우우기타조합.
Objective To establish a serological diagnostic method about NSCLC by investigating the expres-sion of 3 tumor markers of the sulfate glycosaminoglyean fragments(SGF), TSGF and CEA in NSCLC patients' serum. Methods To assay the level of SGF,TSGF and CEA in 50 NSCLC patients with latex particleagglutiation test,colori-metry of biochemistry and CLIA, respectively. Compared the clinical value of different examination combination way in NSCLC diagnosis value. Results There was high difference value between the Ⅰ - Ⅱ stage and the Ⅲ time,the Ⅲ time and the Ⅳ time about the level of SGF(P <0.05) in NSCLC patients. The specificity between SGF,TSGF and CEA each single item and the SGF and TSGF combination examination were not significant(P > 0.05). The semitivity between the SGF and TSGF combination and the SGF,TSGF and CEA combination was not significant(P >0.05), its specificity had significant difference(P <0.05). Conclusions There are higher expression about the 3 tumor mark-ers in NSCLC patients' serum. In the different combination examination, SGF and TSGF combined has great clinical value than other combinations to diagnosis NSCLC.