中华创伤杂志
中華創傷雜誌
중화창상잡지
Chinese Journal of Traumatology
2011年
6期
555-558
,共4页
高伟%贺晓生%章翔%费舟%顼红雨%霍军丽%陈晓燕
高偉%賀曉生%章翔%費舟%頊紅雨%霍軍麗%陳曉燕
고위%하효생%장상%비주%욱홍우%곽군려%진효연
脑损伤%海马%受体,糖皮质激素%认知障碍
腦損傷%海馬%受體,糖皮質激素%認知障礙
뇌손상%해마%수체,당피질격소%인지장애
Brain injuries%Hippocampus%Receptors,gucocortiocid%Cognitive dysfunction
目的 研究创伤性脑损伤(traumatic brain injury,TBI)后大鼠海马区糖皮质激素受体(ghcocorticoid receptor,GR)表达的变化对认知功能的影响.方法 建立大鼠脑损伤模型,应用免疫组化、Western blot和Morris水迷宫检测伤后大鼠海马区GR表达与学习记忆功能的关系.结果伤后4～10 d大鼠海马区GR持续低表达;Morris水迷宫检测伤后大鼠出现认知功能障碍.结论 TBI大鼠海马区GR表达变化与认知功能的障碍改变具有相关性.
目的 研究創傷性腦損傷(traumatic brain injury,TBI)後大鼠海馬區糖皮質激素受體(ghcocorticoid receptor,GR)錶達的變化對認知功能的影響.方法 建立大鼠腦損傷模型,應用免疫組化、Western blot和Morris水迷宮檢測傷後大鼠海馬區GR錶達與學習記憶功能的關繫.結果傷後4～10 d大鼠海馬區GR持續低錶達;Morris水迷宮檢測傷後大鼠齣現認知功能障礙.結論 TBI大鼠海馬區GR錶達變化與認知功能的障礙改變具有相關性.
목적 연구창상성뇌손상(traumatic brain injury,TBI)후대서해마구당피질격소수체(ghcocorticoid receptor,GR)표체적변화대인지공능적영향.방법 건립대서뇌손상모형,응용면역조화、Western blot화Morris수미궁검측상후대서해마구GR표체여학습기억공능적관계.결과상후4～10 d대서해마구GR지속저표체;Morris수미궁검측상후대서출현인지공능장애.결론 TBI대서해마구GR표체변화여인지공능적장애개변구유상관성.
Objective To explore the effect of glucocorticoid receptor(GR)expression in rat hippocampus on cognitive function after traumatic brain injury(TBI). Methods The TBI model wag established in rats.Then,immunohistochemistry and Western blot were used to detect the GR expression and evaluate its relation with cognitire dysfunction by Morris water maze. Results Expression of hippocampal GR was down-regulated 4-10 days after TBI.Morris water maze test showed significant impairment of the cognitive function in rats. Conclusion There is correlation between expression change of hippocampal GR and cognitive dysfunction.
