CAJ | 학술논문

以HER-2原癌基因Ile655Val多态性、吸烟与乳腺癌之间的关联研究为例,运用大样本近似原理计算检验效能,并通过逐步提高对照组中匹配因素的比例,探索弹性匹配策略在环境与基因交互作用分析中的应用价值及其效能计算方法 .HER-2基因多态和吸烟交互作用的检验效能在非匹配的病例对照研究中为30%,应用传统的频数匹配则提高为56%,进一步增加对照组的吸烟率,则能获得更高的效能值(power=74%).结论 :与非匹配或频数匹配的病例对照研究相比,应用弹性匹配的病例对照研究,能够显著增加环境与基因交互作用的检验效能和研究效率,此匹配策略尤其适用于人群中环境暴露率较低、环境暴露与基因易感性呈负向关联或匹配对照例数较少等情况.在研究设计时可充分权衡检验效能的提高与匹配成本的增加,从而选择最佳的匹配策略.
이HER-2원암기인Ile655Val다태성、흡연여유선암지간적관련연구위례,운용대양본근사원리계산검험효능,병통과축보제고대조조중필배인소적비례,탐색탄성필배책략재배경여기인교호작용분석중적응용개치급기효능계산방법 .HER-2기인다태화흡연교호작용적검험효능재비필배적병례대조연구중위30%,응용전통적빈수필배칙제고위56%,진일보증가대조조적흡연솔,칙능획득경고적효능치(power=74%).결론 :여비필배혹빈수필배적병례대조연구상비,응용탄성필배적병례대조연구,능구현저증가배경여기인교호작용적검험효능화연구효솔,차필배책략우기괄용우인군중배경폭로솔교저、배경폭로여기인역감성정부향관련혹필배대조례수교소등정황.재연구설계시가충분권형검험효능적제고여필배성본적증가,종이선택최가적필배책략.
Flexible matching has recently been proposed as a method of improving interactions efficiency. In this study, the concept of flexible matching has been introduced, and the applicability of this strategy has also been described based on the power calculation of interaction between HER-2 polymorphism and smoking with breast cancer. A large-sample approximation method is used to estimate the power and efficiency of gene-environment interactions. In the basic scenario, power of interaction between HER-2 polymorphism and smoking of unmatched case-control study appears to be 30% while in the frequency matching case-control study it is 56%. However, when increasing the smoking prevalence in controls, greater power can be obtained (power=74%). Conclusions: Flexible matching strategies can increase the power and efficiency of case-control studies to detect and estimate the gene-environment interactions when compared with traditional frequency matching and it is especially useful under those scenarios when low environmental exposure of population, adverse gene-environment interactions or less paired controls are seen. Optimal matching design should be made available by weighing the benefits and loss due to flexible matching.