中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2009年
4期
280-283
,共4页
谭泽锋%郭亚东%徐安定%杨万勇%付耀高%王彤歌
譚澤鋒%郭亞東%徐安定%楊萬勇%付耀高%王彤歌
담택봉%곽아동%서안정%양만용%부요고%왕동가
卒中%脑缺血发作,短暂性%西司他汀类
卒中%腦缺血髮作,短暫性%西司他汀類
졸중%뇌결혈발작,단잠성%서사타정류
Stroke%Ischemic attack,transient%Cystatins
目的 探讨国人缺血性卒中/短暂性脑缺血发作(TIA)危险分层下的他汀类药物达标剂量.方法 纳入2007年1-12月在暨南大学附属第一医院神经内科102例患者,将起病<6个月的缺血性卒中/TIA患者使用不同剂量阿托伐他汀(10~80 mg/d)分为常规、强化和常规剂量非达标3组.观察12周内LDL-C达标率、卒中复发及其他血管事件,阿托伐他汀与LDL-C降幅的最效关系.结果 102例患者中,极高危患者达56%.常规和强化剂量达标组2~12周LDL-C达标率为77%~85%,显著高于常规剂量非达标组(10%~15%,P<0.001).3组99例随访12周内再发卒中/其他血管事件、安全性指标差异无统计学意义.2~12周阿托伐他汀10、20、40和80 mg/d的LDL-C降幅分别为32%~35%,46%~49%,51%~52%和印%~65%.结论 半数以上缺血性卒中/TIA患者需要强化他汀类药物治疗,临床应采用危险分层下的他汀类药物达标剂量.国人阿托伐他汀与LDL-C降幅的量效关系与国外研究结果基本一致.
目的 探討國人缺血性卒中/短暫性腦缺血髮作(TIA)危險分層下的他汀類藥物達標劑量.方法 納入2007年1-12月在暨南大學附屬第一醫院神經內科102例患者,將起病<6箇月的缺血性卒中/TIA患者使用不同劑量阿託伐他汀(10~80 mg/d)分為常規、彊化和常規劑量非達標3組.觀察12週內LDL-C達標率、卒中複髮及其他血管事件,阿託伐他汀與LDL-C降幅的最效關繫.結果 102例患者中,極高危患者達56%.常規和彊化劑量達標組2~12週LDL-C達標率為77%~85%,顯著高于常規劑量非達標組(10%~15%,P<0.001).3組99例隨訪12週內再髮卒中/其他血管事件、安全性指標差異無統計學意義.2~12週阿託伐他汀10、20、40和80 mg/d的LDL-C降幅分彆為32%~35%,46%~49%,51%~52%和印%~65%.結論 半數以上缺血性卒中/TIA患者需要彊化他汀類藥物治療,臨床應採用危險分層下的他汀類藥物達標劑量.國人阿託伐他汀與LDL-C降幅的量效關繫與國外研究結果基本一緻.
목적 탐토국인결혈성졸중/단잠성뇌결혈발작(TIA)위험분층하적타정류약물체표제량.방법 납입2007년1-12월재기남대학부속제일의원신경내과102례환자,장기병<6개월적결혈성졸중/TIA환자사용불동제량아탁벌타정(10~80 mg/d)분위상규、강화화상규제량비체표3조.관찰12주내LDL-C체표솔、졸중복발급기타혈관사건,아탁벌타정여LDL-C강폭적최효관계.결과 102례환자중,겁고위환자체56%.상규화강화제량체표조2~12주LDL-C체표솔위77%~85%,현저고우상규제량비체표조(10%~15%,P<0.001).3조99례수방12주내재발졸중/기타혈관사건、안전성지표차이무통계학의의.2~12주아탁벌타정10、20、40화80 mg/d적LDL-C강폭분별위32%~35%,46%~49%,51%~52%화인%~65%.결론 반수이상결혈성졸중/TIA환자수요강화타정류약물치료,림상응채용위험분층하적타정류약물체표제량.국인아탁벌타정여LDL-C강폭적량효관계여국외연구결과기본일치.
Objective To explore statin dosages for targeting goal of LDL-C lowering on the basis of stroke risk stratification and the dosage-effective relation of statin and LDL-C lowering in Chinese patients with ischemic stroke and transient ischemic attack (TIA).Methods This is a prospective and open clinical trial patients with ischemic stroke/TIA within 6 months were enrolled and the dosages of atorvastatin were calculated based on risk stratification according to "Chinese Consensus for Prevention of Ischemic Stroke/TIA with Statin" (Chinese Consensus).A dose of 10 mg of atorvastatin daily to target LDL-C goal was takenas the standard dosage targeting goal (SDTG).Patients taking this dosage of atorvastatin constituted a SDTG group.Those who needed a daily dose of 20 mg or more of atorvastatin were randomized into an intensive dosage targeting goal (IDTG) group ( atorvastatin 20-80 mg/d) and a standard dosage non-targeting goal (SDNTG) group (atorvastatin 10 mg/d without targeting goal).All patients took atorvastatin for 12 weeks.The primary outcome was the rate of targeting goal for LDL-C lowering at 2,4 and 12 weeks,respectively and the secondary outcome was the occurence of recurrent stroke and other vascular events within 12 weeks.The main safety endpoint was serial adverse events including symptomatic intracranial hemorrhage.Results Altogether 102 cases were enrolled and 99 cases were followed up for 12 weeks.According to the Chinese Consensus,the rate of high risk,very high risk- Ⅰ and very high risk- Ⅱ was 44% ,28% and 28%,respectively.Targeting rate for LDL-C lowering was 77% -85% at each time point in the SDTG and IDTG groups ,being significantly higher than those in the SDNTG group ( 12% -16%,P < 0.01 ).No significant difference was found concerning the occurrence of recurrent stroke,other vascular events and safety endpoints among the three groups.The amplitude of LDL-C lowering was 32%-35% ,46%-49% ,51%-52% and 60%-65% with corresponding to daily dosage of 10 mg,20 mg,d0 mg and 80 mg atorvastatin.Conclusions At least more than half of the patients after iscbemic stroke/TIA need intensive statin therapy to target the LDL-C lowering goal.The dosage- effective relation of atorvastatin and LDL-C lowering in Chinese is similar to the reported data in other races.