中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2011年
5期
374-376
,共3页
于吉广%刘友德%乔令艳%王春娟
于吉廣%劉友德%喬令豔%王春娟
우길엄%류우덕%교령염%왕춘연
手足口病%流行病学%临床医学
手足口病%流行病學%臨床醫學
수족구병%류행병학%림상의학
Hand foot and mouth disease%Epidemiology%Clinical manifestation
目的 了解烟台地区手足口病住院病例的流行病学及临床特征.方法 回顾性分析我院2009-2010年住院的手足口病患儿的流行病学及临床资料.结果 931例中,5岁以下儿童881例,占94.6％,男女之比为1.5∶1;全部患儿(100.0％)均有皮疹,840例(90.2％)患儿发热,神经系统受累者121(13.0％)例.病例集中就诊于4-9月份,共计828例,占88.9％;月病例数与月平均气温呈正相关(r =0.887,P＜0.001).单因素分析显示,22(2.4％)例重症病例中农村儿童比例、发热持续时间、血清CRP水平和空腹血糖水平均显著高于普通病例;多因素分析发现,只有发热持续时间和空腹血糖水平是重症病例的独立预测因素,其比值比OR(95％ CI)分别为1.491(1.170～1.901)和1.124(1.016～1.245),P值分别为0.001和0.024.结论 本地区手足口病好发于5岁以下儿童,发病高峰为4～9月份,与本地区月平均气温正相关;发热持续时间和空腹血糖水平是重症病例的独立预测因素.多数患儿只要早诊断、早治疗,预后一般良好.
目的 瞭解煙檯地區手足口病住院病例的流行病學及臨床特徵.方法 迴顧性分析我院2009-2010年住院的手足口病患兒的流行病學及臨床資料.結果 931例中,5歲以下兒童881例,佔94.6％,男女之比為1.5∶1;全部患兒(100.0％)均有皮疹,840例(90.2％)患兒髮熱,神經繫統受纍者121(13.0％)例.病例集中就診于4-9月份,共計828例,佔88.9％;月病例數與月平均氣溫呈正相關(r =0.887,P＜0.001).單因素分析顯示,22(2.4％)例重癥病例中農村兒童比例、髮熱持續時間、血清CRP水平和空腹血糖水平均顯著高于普通病例;多因素分析髮現,隻有髮熱持續時間和空腹血糖水平是重癥病例的獨立預測因素,其比值比OR(95％ CI)分彆為1.491(1.170～1.901)和1.124(1.016～1.245),P值分彆為0.001和0.024.結論 本地區手足口病好髮于5歲以下兒童,髮病高峰為4～9月份,與本地區月平均氣溫正相關;髮熱持續時間和空腹血糖水平是重癥病例的獨立預測因素.多數患兒隻要早診斷、早治療,預後一般良好.
목적 료해연태지구수족구병주원병례적류행병학급림상특정.방법 회고성분석아원2009-2010년주원적수족구병환인적류행병학급림상자료.결과 931례중,5세이하인동881례,점94.6％,남녀지비위1.5∶1;전부환인(100.0％)균유피진,840례(90.2％)환인발열,신경계통수루자121(13.0％)례.병례집중취진우4-9월빈,공계828례,점88.9％;월병례수여월평균기온정정상관(r =0.887,P＜0.001).단인소분석현시,22(2.4％)례중증병례중농촌인동비례、발열지속시간、혈청CRP수평화공복혈당수평균현저고우보통병례;다인소분석발현,지유발열지속시간화공복혈당수평시중증병례적독립예측인소,기비치비OR(95％ CI)분별위1.491(1.170～1.901)화1.124(1.016～1.245),P치분별위0.001화0.024.결론 본지구수족구병호발우5세이하인동,발병고봉위4～9월빈,여본지구월평균기온정상관;발열지속시간화공복혈당수평시중증병례적독립예측인소.다수환인지요조진단、조치료,예후일반량호.
Objective To discuss the epidemiological and clinical characteristics of the hospitalized children with hand foot and mouth disease (HFMD) in Yantai area.Methods Epidemiological and clinical data of HFMD children from 2009 to 2010 were summarized and analyzed retrospectively.Results Most of the infected ( 94.6％ ) were under 5 years old and the ratio between male and female was 1.5∶1.Oral mucosal pox or ulcer as well as hand and foot rashes were observed in all 931 patients.Fever and neurological disorders occurred in 840( 90.2％ )and 121 (13.0％) patients respectively.The incidence was positively correlated with air temperature ( r =0.887,P ＜ 0.001 ),with a peak in April to September (88.9％).The ratio of children from countryside,total duration of fever,serum concentration of c-reacting protein (CRP) and fasting blood glucose(FBG) were significantly higher in severe cases than in those mild ones.Multivariate analysis showed longer mean duration of fever( Odds ratio[ OR],1.491 ;95％ confidence interval[ CI] 1.170-1.901 ;P =0.001 ) and hyperglycemia( OR,1.124; 95％ CI 1.016-1.245 ; P =0.024 )were independent risk factors of severity.Conclusion Children younger than 5 years old are susceptible to HFMD and most cases occur in April to September.The monthly incidence is positively correlated with temperature of that month.Longer duration of fever and hyperglycemia are independent risk factors for severity.Most cases could have a favorable prognosis after timely diagnosis and proper intervention.
