Smad3基因剔除小鼠的基因型鉴定与繁殖性能研究
Smad3기인척제소서적기인형감정여번식성능연구
Research of the Genotype Identification and Riproductive Performance of Smad3 Gene Knockout Mice
  • 万方数据
    实验动物科学与管理 실험동물과학여관리
    LABORATORY ANIMAL SCIENCE AND MANAGEMENT
    2003年 z1期 129-130 ,共2页

    孙岩松%吕雅歆%王冬平%方厚华%时彦胜%战大伟%张爱兰%李桂军

    손암송%려아흠%왕동평%방후화%시언성%전대위%장애란%리계군

    Smad3基因剔除小鼠%繁殖%基因型鉴定 Smad3基因剔除小鼠%繁殖%基因型鑒定
    Smad3기인척제소서%번식%기인형감정


    The previous study of Srnad3 gene knockout mice ( Smad3ex8/ex8 ) shows that the Smad3ex8/ex8 mice develop progressive leukocytosis, periodontitis, gastritis, colitis and chronic infection with abscess formation adjacent to mucosal surfaces . symptomatic mutant mice exhibit thymic involution, enlarged lymph nodes and T cells with activated phenotype.Further study suggests that the thymic cells and peripheral T ceels of Smad3ex8/ex8 mice have lost the response to TGF-β.Furthermore, nwe found that the homologous Smad3ex8/ex mice developed degenerative joint disease resembling human osteoarthritis, osteoporosis and wound healing up quicker. So the mice can serve as an ideal animal model for immune dysregulation, osteoarthritis and so on.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문