CAJ | 학술논문

目的:观察肉毒杆菌毒素A(BTA)治疗先天性眼球震颤(CN)的效果.方法:先天性眼球震颤患者22例,男17例,女5例.用眼震图(ENG)检查BTA注射相应眼外肌前与注射后1wk,1,3,6mo的近、远距离眼震,视力,3级视功能情况,各组进行统计学处理,并比较统计学差异.结果:各组注药前后视力改变无统计学差异(P>0.05).注药后lmo与注药前相比,远近距离原眼位的各眼震参数降低均有明显统计学差异(P＜0.05);注药后3,6mo与注药前相比近、远距离原眼位振幅降低有明显统计学差异(P＜0.05);最小震强位置注药后1wk,1,3,6mo与注药前相比虽无明显差异,但从频数分布图中可见最小震强出现的位置有向原眼位集中的趋势.注药后3,6mo 3级视功能与注药前相比仅融合范围扩大有显著差异(P＜0.05).结论:该方法治疗先天性眼球震颤可使近、远距离原眼位眼震有所减轻,视力、代偿头位及3级视功能有所改善.注药后1mo疗效最显著,6mo后疗效下降.该方法治疗先天性眼球震颤有明显效果.
목적:관찰육독간균독소A(BTA)치료선천성안구진전(CN)적효과.방법:선천성안구진전환자22례,남17례,녀5례.용안진도(ENG)검사BTA주사상응안외기전여주사후1wk,1,3,6mo적근、원거리안진,시력,3급시공능정황,각조진행통계학처리,병비교통계학차이.결과:각조주약전후시력개변무통계학차이(P>0.05).주약후lmo여주약전상비,원근거리원안위적각안진삼수강저균유명현통계학차이(P＜0.05);주약후3,6mo여주약전상비근、원거리원안위진폭강저유명현통계학차이(P＜0.05);최소진강위치주약후1wk,1,3,6mo여주약전상비수무명현차이,단종빈수분포도중가견최소진강출현적위치유향원안위집중적추세.주약후3,6mo 3급시공능여주약전상비부융합범위확대유현저차이(P＜0.05).결론:해방법치료선천성안구진전가사근、원거리원안위안진유소감경,시력、대상두위급3급시공능유소개선.주약후1mo료효최현저,6mo후료효하강.해방법치료선천성안구진전유명현효과.
AIM: To investigate the effect of botulin A (BTA) on patients with congenital nystagmus (CN).METHODS: Twenty-two CN patients (44 eyes, including5 females and 17 males) were treated with BTA of the lowest effective dosage injected directly into the patients'correlative extrocular muscles. The changes in ocular nystagmus were measured by electronystagmography (ENG)before the BTA injection and one week, one month, three months, and half a year afterwards. Meanwhile the changes in visual acuity and three-degree visual function were also measured.RESULTS: Visual acuity at different time before and after the injection did not show significant changes (P＞0.05). Compared with the nystagmus data in the near-and far-distance primary positions before the injection, they all decreased significantly 1 month after the injection (P＜0.05). Compared with the nystagmus amplitude in the near-and far-distance primary positions before the injection, it decreased significantly three months and half a year after injection (＜0.05). The lowest intensity position, which reflected the changes of compensatory head postures, did not change obviously after injection, although it showed the tendency of becoming closer to the primary eye position. As for three-degree binocular vision, the fusion range amplified significantly 3 and 6months after injection (P＜0.05).CONCLUSION: This treatment of CN is proved effectivein reducing nystagmus at the primary eye position, improving the compensatory head postures, visual acuity and three-degree binocular vision to some extent. The most effective period occurs at one month after injection.The effect begins to reduce six months after the injection when compared with that at one month.