中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
2期
119-121
,共3页
齐印宝%傅先明%王昌新%钱若兵%魏祥品
齊印寶%傅先明%王昌新%錢若兵%魏祥品
제인보%부선명%왕창신%전약병%위상품
海洛因依赖%静息态功能性磁共振%低频振荡幅度
海洛因依賴%靜息態功能性磁共振%低頻振盪幅度
해락인의뢰%정식태공능성자공진%저빈진탕폭도
Heroin abuse%Resting state fMRI%ALFF
目的 采用静息态功能性磁共振成像的低频振幅技术,探讨海洛因依赖者脑活动的神经机制及其意义.方法 运用功能性磁共振技术观察海洛因成瘾者的脑血氧水平依赖信号的改变;对15例海洛因海洛因依赖者和15名正常志愿者进行静息态数据采集,然后运用低频振幅算法对采集后的静息态数据进行分析,得到每个被试的低频振幅统计图,最后对两组进行双样本t检验,以P＜0.05,t＞2.060为阈值显示海洛因依赖者相对于正常人ALFF增高和减弱的区域.结果 海洛因依赖组和正常对照组相比ALFF减弱的脑区分布在右颞叶(45,-30,-21)、左侧海马(-36,-33,-6)、右侧丘脑(24,-12,27)、左侧后扣带回(-15,-54,24)、右侧顶叶及楔前叶(21,-51,36)、右侧顶下小叶(45,-42,63)、右侧额叶背外侧面(21,-48,78);而海洛因依赖组在左侧前额叶(0,39,72)ALFF明显高于对照组.结论 海洛因依赖者静息状态下表现出异常的脑功能活动方式,这些异常的活动可能与海洛因依赖的产生、维持及戒断后复吸密切相关.
目的 採用靜息態功能性磁共振成像的低頻振幅技術,探討海洛因依賴者腦活動的神經機製及其意義.方法 運用功能性磁共振技術觀察海洛因成癮者的腦血氧水平依賴信號的改變;對15例海洛因海洛因依賴者和15名正常誌願者進行靜息態數據採集,然後運用低頻振幅算法對採集後的靜息態數據進行分析,得到每箇被試的低頻振幅統計圖,最後對兩組進行雙樣本t檢驗,以P＜0.05,t＞2.060為閾值顯示海洛因依賴者相對于正常人ALFF增高和減弱的區域.結果 海洛因依賴組和正常對照組相比ALFF減弱的腦區分佈在右顳葉(45,-30,-21)、左側海馬(-36,-33,-6)、右側丘腦(24,-12,27)、左側後釦帶迴(-15,-54,24)、右側頂葉及楔前葉(21,-51,36)、右側頂下小葉(45,-42,63)、右側額葉揹外側麵(21,-48,78);而海洛因依賴組在左側前額葉(0,39,72)ALFF明顯高于對照組.結論 海洛因依賴者靜息狀態下錶現齣異常的腦功能活動方式,這些異常的活動可能與海洛因依賴的產生、維持及戒斷後複吸密切相關.
목적 채용정식태공능성자공진성상적저빈진폭기술,탐토해락인의뢰자뇌활동적신경궤제급기의의.방법 운용공능성자공진기술관찰해락인성은자적뇌혈양수평의뢰신호적개변;대15례해락인해락인의뢰자화15명정상지원자진행정식태수거채집,연후운용저빈진폭산법대채집후적정식태수거진행분석,득도매개피시적저빈진폭통계도,최후대량조진행쌍양본t검험,이P＜0.05,t＞2.060위역치현시해락인의뢰자상대우정상인ALFF증고화감약적구역.결과 해락인의뢰조화정상대조조상비ALFF감약적뇌구분포재우섭협(45,-30,-21)、좌측해마(-36,-33,-6)、우측구뇌(24,-12,27)、좌측후구대회(-15,-54,24)、우측정협급설전협(21,-51,36)、우측정하소협(45,-42,63)、우측액협배외측면(21,-48,78);이해락인의뢰조재좌측전액협(0,39,72)ALFF명현고우대조조.결론 해락인의뢰자정식상태하표현출이상적뇌공능활동방식,저사이상적활동가능여해락인의뢰적산생、유지급계단후복흡밀절상관.
Objective To study the changes of amplitude of low-frequency fluctuation (ALFF) of the resting state fMRI in heroin abuser (HD), and discussed its underlying neurophysiological mechanism.Methods The resting state fMRI data of 15 heroin abusers and 15 normal volunteers were analyzed by ALFF.The amplitude of the blood oxygenation level dependent activation of the resting state brain was investigated.The brain structures showing increased and decreased ALFF in TLE patients were demonstrated by comparing to normal subjects with 2-sample t -test with threshold of P＜0.05.Results Compared with normal subjects,the regions showing decreased ALFF in HD patients were distributed in right temporal lobe(45, - 30, -21 ) ,left hippocampus( - 36,- 33, - 6), right thalamus ( 24, - 12,27 ), left posterior cingulum gyrus ( - 15, - 54,24 ), right parietal lobe /precuneus ( 21, - 51,36 ), right inferior parietal lobule ( 21, - 48,78 ) and dorsal lateral aspect of the right frontal lobe(21, - 48,78) ,while ALLF of left(45, - 42,63 ) lateral frontal cortex(0 ,39,72) in HD patients was significantly higher.Conclusion HD shows abnormal brain functional organization in resting state, which may play an important role in the production, maintenance and relapse after withdrawal of heroin abuse.
