CAJ | 학술논문

自然杀伤性T细胞(NKT)和树突状细胞(DC)等免疫细胞作为免疫系统的重要组成成份在维持机体内环境的稳态和免疫功能的正常发挥中起着至关重要的作用.近年的研究发现,鞘氨醇-1-磷酸(SIP)及其受体相互作用不仅可以影响免疫细胞的迁移,而且还能改变多种免疫细胞如NKT细胞、DC、CD4+ CD25+调节性T细胞(Treg)等的功能,从而引起机体免疫反应的变化.与此信号通路相关的多种动物实验和临床试验研究均证明了免疫调节剂FTY720即鞘氨醇-1-磷酸受体1(S1PR1)的拮抗剂在疾病的诊断和治疗中具有广泛的应用前景.
자연살상성T세포(NKT)화수돌상세포(DC)등면역세포작위면역계통적중요조성성빈재유지궤체내배경적은태화면역공능적정상발휘중기착지관중요적작용.근년적연구발현,초안순-1-린산(SIP)급기수체상호작용불부가이영향면역세포적천이,이차환능개변다충면역세포여NKT세포、DC、CD4+ CD25+조절성T세포(Treg)등적공능,종이인기궤체면역반응적변화.여차신호통로상관적다충동물실험화림상시험연구균증명료면역조절제FTY720즉초안순-1-린산수체1(S1PR1)적길항제재질병적진단화치료중구유엄범적응용전경.
Immune cells,such as natural killer T cells(NKT)and dendritic cells(DCs),play an important role in maintaining homeostasis and operating immunity functions in the internal environment.Recently research showed that Sphingosine-1-phosphate(S1P)and its receptors could influence the migration and functions of many immune cells,such as(NKT)cells,DCs,and CD4+ CD25+ Treg cells,and lead to further immune responses.In many animals experiments and clinic trials,it was indicated that FTY720,as known as S1PR1 agonist,functioned through the signal pathway related with S1P and had a wide clinical applications in disease diagnosis and therapy.