CAJ | 학술논문

目的研究老年非小细胞肺癌患者细胞免疫功能变化及化疗对其影响.方法分别测定初次确诊的老年非小细胞肺癌患者29例、中青年非小细胞肺癌患者20例及健康老年人22例的T淋巴细胞亚群( CD3、CD4、CD8、CD4/CD8)及自然杀伤(NK)细胞的值,同时比较老年非小细胞肺癌患者化疗前和2个周期化疗结束、第3个周期开始前的T淋巴细胞亚群及NK细胞的数值.结果老年非小细胞肺癌患者CD3、CD4、CD8、CD4/CD8及NK细胞分别为58.9±15.8、32.3±12.7、22.0±9.8、1.3±0.7、21.6±7.7,与中青年非小细胞肺癌患者65.9±7.2、38.5±7.6、23.1±9.2、1.5±0.7、16.8±6.2相比,CD3、CD4细胞降低,NK细胞增加(t=2.109、2.159、2.273,均P＜0.05),CD8、CD4/CD8变化差异无统计学意义(t=0.406、0.736,均P＞0.05)；与健康老年人67.3±9.0、39.0±7.8、23.9±9.3、2.0±1.6、22.5±5.8比较,CD3、CD4、CD4/CD8明显降低(t=2.234、2.200、2.016,均P＜0.05),CD8、NK细胞变化差异无统计学意义(t=0.700、0.474,均P＞0.05)；老年非小细胞肺癌患者化疗后分别为51.6±10.3、31.7±11.7、21.6±6.5、1.3±0.7、26.0±12.7,CD3明显减低(t=2.067,P＜0.05),CD4、CD8、CD4/CD8及NK细胞变化,差异无统计学意义(t=0.186、0.180、0.289、1.570,均P＞0.05).结论老年非小细胞肺癌患者较中青年非小细胞肺癌患者及健康老年人免疫功能减低,化疗可进一步降低其细胞免疫功能.
목적 연구노년비소세포폐암환자세포면역공능변화급화료대기영향.방법 분별측정초차학진적노년비소세포폐암환자29례、중청년비소세포폐암환자20례급건강노년인22례적T림파세포아군( CD3、CD4、CD8、CD4/CD8)급자연살상(NK)세포적치,동시비교노년비소세포폐암환자화료전화2개주기화료결속、제3개주기개시전적T림파세포아군급NK세포적수치.결과 노년비소세포폐암환자CD3、CD4、CD8、CD4/CD8급NK세포분별위58.9±15.8、32.3±12.7、22.0±9.8、1.3±0.7、21.6±7.7,여중청년비소세포폐암환자65.9±7.2、38.5±7.6、23.1±9.2、1.5±0.7、16.8±6.2상비,CD3、CD4세포강저,NK세포증가(t=2.109、2.159、2.273,균P＜0.05),CD8、CD4/CD8변화차이무통계학의의(t=0.406、0.736,균P＞0.05)；여건강노년인67.3±9.0、39.0±7.8、23.9±9.3、2.0±1.6、22.5±5.8비교,CD3、CD4、CD4/CD8명현강저(t=2.234、2.200、2.016,균P＜0.05),CD8、NK세포변화차이무통계학의의(t=0.700、0.474,균P＞0.05)；노년비소세포폐암환자화료후분별위51.6±10.3、31.7±11.7、21.6±6.5、1.3±0.7、26.0±12.7,CD3명현감저(t=2.067,P＜0.05),CD4、CD8、CD4/CD8급NK세포변화,차이무통계학의의(t=0.186、0.180、0.289、1.570,균P＞0.05).결론 노년비소세포폐암환자교중청년비소세포폐암환자급건강노년인면역공능감저,화료가진일보강저기세포면역공능.
Objective To investigate changes of the cellular immune function in the elderly patients with nonsmall-cell lung cancer (NSCLC) after chemotherapy.Methods T-lymphocyte subsets and natural killer cell were detected in 29 elderly patients with NSCLC,20 adults with NSCLC and 22 healthy elderly,and their levels were compared between pre-chemotherapy and at the end of 2 cycles of chemotherapy in the elderly patients with NSCLC.Results The levels of CD3,CD4,CD8,CD4/CD8andNK cell were (58.9±15.8),(32.3±12.7),(22.0±9.8),(1.3±0.7),(21.6± 7.7),respectively in the elderly patients with NSCLC,(65.9 ± 7.2),(38.5 ± 7.6),(23.1 ± 9.2),(1.5±0.7),(16.8±6.2),respectively in adults with NSCLC and (67.3±9.0),(39.0±7.8),(23.9±9.3),(2.0±1.6),(22.5±5.8),respectively in healthy elderly.The levels of CD3 and CD4 were decreased (t=2.109,2.159,P＜0.05) and NK cell was increased (t=2.273,P＜0.05) while CD8 and CD4/CD8 had no difference(t = 0.406,0.736,P＞ 0.05 ) in the elderly patients with NSCLC as compared with adults with NSCLC.The levels of CD3,CD4,and CD4/CD8 were lower (t = 2.234,2.200,2.016,all P＜ 0.05) in elderly patients with NSCLC than in healthy elderly,with no significant change in the levels of CD8 and NK cell(t= 0.700,0.474,P＞0.05) between the two groups.The levels of CD3 (51.6 ±10.3)was reduced(t=2.067,P＜0.05) and CD4 (31.7 ± 11.7),CD8(21.6 ± 6.5),CD4/CD8 (1.3 ± 0.7),NK cell (26.0 ±12.7)had no remarkable difference (t =0.186,0.180,0.289,1.570,all P＞ 0.05)after chemotherapy in elderly patients with NSCLC.Conclusions The cellular immune function in the elderly patients with NSCLC is lower than in adults with NSCLC and healthy elderly,and further decreases after chemotherapy.