CAJ | 학술논문

探讨继发于伞垂体功能减退的甲状腺功能减退(继发性甲减)患儿的激素改变及治疗.测定1999年9月至2006年3月以生长迟缓就诊于山东省市医院儿科的57例继发性甲减患儿垂体-靶腺激素,同时观察激素替代治疗的合适剂量.57例继发性甲减患儿FT_4均降低,初诊时19例(33.3%)TSH低于正常,38例(66.7%)TSH正常或略高,但L-T_4有效治疗后55例(96.5%)TSH低于正常.57例患儿均伴有生长激素缺乏及垂体MRI影像异常.继发性甲减常伴有全垂体功能减退和MRI异常,其治疗目标应使FT_4尽快达到并维持在正常上限.
탐토계발우산수체공능감퇴적갑상선공능감퇴(계발성갑감)환인적격소개변급치료.측정1999년9월지2006년3월이생장지완취진우산동성시의원인과적57례계발성갑감환인수체-파선격소,동시관찰격소체대치료적합괄제량.57례계발성갑감환인FT_4균강저,초진시19례(33.3%)TSH저우정상,38례(66.7%)TSH정상혹략고,단L-T_4유효치료후55례(96.5%)TSH저우정상.57례환인균반유생장격소결핍급수체MRI영상이상.계발성갑감상반유전수체공능감퇴화MRI이상,기치료목표응사FT_4진쾌체도병유지재정상상한.
To explore the pituitary-thyroid hormone levels and hormone replacement therapy(HRT)in children with secondary hypothyroidism.From September 1999 to March 2006,57 patients with growth retardation and diagnosis of secondary hypothyroidism were enrolled.Serum pituitary hormones were measured,MRI on hypothalamus and pituitary area was evaluated and the appropriate dosage of HRT was investigated.The serum FT_4levels were significantly decreased in all 57 patients(100%)with secondary hypothyroidism.TSH levels were lowered in 19 patients on diagnosis,and within normal range or slightly elevated in the other 38 cases(66.7%).After levothyroxine(L-T_4)treatment,TSH levels were lowered in 55 patients(96.5%).Growth hormone deficiency and abnormal MRI images were found in all patients(100.0%).Secondary hypothyroidism were often associated with multiple pituitary hormone deficiency and abnormal MRI manifestations.FT_4 should be maintained within middle to upper limit of normal range,and the hormone levels should be monitored regularly.