中华微生物学和免疫学杂志
中華微生物學和免疫學雜誌
중화미생물학화면역학잡지
CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY
2009年
11期
1014-1016
,共3页
黄卫青%赵自云%马艳辉%江秀爱
黃衛青%趙自雲%馬豔輝%江秀愛
황위청%조자운%마염휘%강수애
肺炎链球菌%耐药性%耐青霉素肺炎链球菌
肺炎鏈毬菌%耐藥性%耐青黴素肺炎鏈毬菌
폐염련구균%내약성%내청매소폐염련구균
Streptococcus pneumoniae%Drug resistance%Resistant to penicillin Streptococcus pneumoniae
目的 监测青岛地区肺炎链球菌的耐药性,为临床合理应用抗菌药物提供依据.方法 采集青岛地区部分医院2005年1月到2008年12月门诊与住院感染患者呼吸道、血液、脑脊液等标本,培养、分离和鉴定肺炎链球菌.根据NCCLS的推荐,采用琼脂微茸稀释法测定分离出的231株肺炎链球菌对11种常用抗菌药物的耐药性,分析耐药趋势及年龄差异.结果 231株肺炎链球菌对青霉素不敏感率为23.38%[耐青霉素肺炎链球菌(PRSP):9.52%;低耐青霉素肺炎链球菌(PISP):13.85%].对头孢噻肟耐药率最低为9.96%(23/231),其次阿莫西林为12.55%(29/231).对红霉素耐药率最高为90.48%(209/231).14岁以下患者PRSP检出率为27.91%(12/43),明显高于成人的PRSP检出率5.38%(10/186).结论 本地区PRSP检出率较2004年前明显增加,并有逐年增加的趋势,肺炎链球菌的耐药性也有逐年上升的趋势.本地区对感染低耐青霉素肺炎链球菌的患者头孢噻肟、阿莫西林可为首选药物.
目的 鑑測青島地區肺炎鏈毬菌的耐藥性,為臨床閤理應用抗菌藥物提供依據.方法 採集青島地區部分醫院2005年1月到2008年12月門診與住院感染患者呼吸道、血液、腦脊液等標本,培養、分離和鑒定肺炎鏈毬菌.根據NCCLS的推薦,採用瓊脂微茸稀釋法測定分離齣的231株肺炎鏈毬菌對11種常用抗菌藥物的耐藥性,分析耐藥趨勢及年齡差異.結果 231株肺炎鏈毬菌對青黴素不敏感率為23.38%[耐青黴素肺炎鏈毬菌(PRSP):9.52%;低耐青黴素肺炎鏈毬菌(PISP):13.85%].對頭孢噻肟耐藥率最低為9.96%(23/231),其次阿莫西林為12.55%(29/231).對紅黴素耐藥率最高為90.48%(209/231).14歲以下患者PRSP檢齣率為27.91%(12/43),明顯高于成人的PRSP檢齣率5.38%(10/186).結論 本地區PRSP檢齣率較2004年前明顯增加,併有逐年增加的趨勢,肺炎鏈毬菌的耐藥性也有逐年上升的趨勢.本地區對感染低耐青黴素肺炎鏈毬菌的患者頭孢噻肟、阿莫西林可為首選藥物.
목적 감측청도지구폐염련구균적내약성,위림상합리응용항균약물제공의거.방법 채집청도지구부분의원2005년1월도2008년12월문진여주원감염환자호흡도、혈액、뇌척액등표본,배양、분리화감정폐염련구균.근거NCCLS적추천,채용경지미용희석법측정분리출적231주폐염련구균대11충상용항균약물적내약성,분석내약추세급년령차이.결과 231주폐염련구균대청매소불민감솔위23.38%[내청매소폐염련구균(PRSP):9.52%;저내청매소폐염련구균(PISP):13.85%].대두포새우내약솔최저위9.96%(23/231),기차아막서림위12.55%(29/231).대홍매소내약솔최고위90.48%(209/231).14세이하환자PRSP검출솔위27.91%(12/43),명현고우성인적PRSP검출솔5.38%(10/186).결론 본지구PRSP검출솔교2004년전명현증가,병유축년증가적추세,폐염련구균적내약성야유축년상승적추세.본지구대감염저내청매소폐염련구균적환자두포새우、아막서림가위수선약물.
Objective To monitor the resistance of Streptococcus pneumoniae following the 2004 in Qingdao area, and to provide a reasonable basis for clinical application of antimicrobial agents. Methods Collecting respiratory tract, blood, cerebrospinal fluid and other specimens from out-patient and in-patients of some hospital in Qingdao from January 2005 to December 2008. According to the recommendation of NCCLS, antibiotic resistance analysis of 11 kinds of antibiotic to the isolated 231 Streptococcus pneumoniae by micro-agar dilution method, and analysis resistance trends and age differences. Results The results showed that the rate of Streptococcus pneumoniae not sensitive to penicillin is 23. 38% (PRSP: 9.52% , PISP: 13. 85% ) , resistant to cefotaxime is 9. 96% (23/231), resistant to amoxicillin is 12. 55% , resistant to erythromycin is 90. 48% (209/231). PRSP rate of patients younger than 14 years of age 27. 91% (12/43), significantly higher than that of the PRSP rate of adults 5. 38% (10/186). Conclusion The rate of resistant to penicillin Streptococcus pneumoniae increased significantly from 2004, and an increasing trend year by year, the resistance of Streptococcus pneumoniae is also a rising trend year by year. For patients infected low penicillin-resistant Streptococcus pneumoniae in this region, cefotaxime, amoxicillin are preferred drugs.
