中国医学影像技术
中國醫學影像技術
중국의학영상기술
CHINESE JOURNAL OF MEDICAL IMAGING TECHNOLOGY
2010年
2期
221-224
,共4页
柴学%张龙江%胡裕效%赵艳娥%薛杨波%胡小波%朱虹%卢光明
柴學%張龍江%鬍裕效%趙豔娥%薛楊波%鬍小波%硃虹%盧光明
시학%장룡강%호유효%조염아%설양파%호소파%주홍%로광명
双能量%灌注成像%肺栓塞%放射性核素显像%模型,动物
雙能量%灌註成像%肺栓塞%放射性覈素顯像%模型,動物
쌍능량%관주성상%폐전새%방사성핵소현상%모형,동물
Dual energy%Perfusion imaging%Pulmonary embolism%Radionuclide imaging%Models,animal
目的 探讨双源CT双能量肺灌注成像(DEPI)与核素肺灌注显像诊断实验性急性肺栓塞的价值.方法 24只家兔,20只采用股静脉入路注射明胶海绵制成急性肺栓塞模型,另外4只注射生理盐水作为对照组.栓塞后2 h行DEPI及核素肺灌注平面显像.以病理结果为金标准,比较两种方法在肺叶基础上诊断急性肺栓塞的准确性.比较增强DEPI图像上栓塞区与正常肺实质的CT值和强化值(Overlay值).结果 对照组DEPI图像表现为大致均匀的黄红色伪彩,栓塞后栓塞区肺灌注图像表现为灌注缺损,核素肺灌注显示栓塞区放射性稀疏或缺损;DEPI和肺灌注平面显像诊断肺栓塞的敏感度、特异度、阳性预测值、阴性预测值分别为100%、97.50%、95.24%、100%;67.50%、81.25%、64.29%、83.33%.增强后栓塞区和非栓塞区CT值及强化值的差异均有统计学意义(P<0.05).结论 与核素肺灌注显像相比,DEPI诊断实验性急性肺栓塞有更高的敏感度和特异度.
目的 探討雙源CT雙能量肺灌註成像(DEPI)與覈素肺灌註顯像診斷實驗性急性肺栓塞的價值.方法 24隻傢兔,20隻採用股靜脈入路註射明膠海綿製成急性肺栓塞模型,另外4隻註射生理鹽水作為對照組.栓塞後2 h行DEPI及覈素肺灌註平麵顯像.以病理結果為金標準,比較兩種方法在肺葉基礎上診斷急性肺栓塞的準確性.比較增彊DEPI圖像上栓塞區與正常肺實質的CT值和彊化值(Overlay值).結果 對照組DEPI圖像錶現為大緻均勻的黃紅色偽綵,栓塞後栓塞區肺灌註圖像錶現為灌註缺損,覈素肺灌註顯示栓塞區放射性稀疏或缺損;DEPI和肺灌註平麵顯像診斷肺栓塞的敏感度、特異度、暘性預測值、陰性預測值分彆為100%、97.50%、95.24%、100%;67.50%、81.25%、64.29%、83.33%.增彊後栓塞區和非栓塞區CT值及彊化值的差異均有統計學意義(P<0.05).結論 與覈素肺灌註顯像相比,DEPI診斷實驗性急性肺栓塞有更高的敏感度和特異度.
목적 탐토쌍원CT쌍능량폐관주성상(DEPI)여핵소폐관주현상진단실험성급성폐전새적개치.방법 24지가토,20지채용고정맥입로주사명효해면제성급성폐전새모형,령외4지주사생리염수작위대조조.전새후2 h행DEPI급핵소폐관주평면현상.이병리결과위금표준,비교량충방법재폐협기출상진단급성폐전새적준학성.비교증강DEPI도상상전새구여정상폐실질적CT치화강화치(Overlay치).결과 대조조DEPI도상표현위대치균균적황홍색위채,전새후전새구폐관주도상표현위관주결손,핵소폐관주현시전새구방사성희소혹결손;DEPI화폐관주평면현상진단폐전새적민감도、특이도、양성예측치、음성예측치분별위100%、97.50%、95.24%、100%;67.50%、81.25%、64.29%、83.33%.증강후전새구화비전새구CT치급강화치적차이균유통계학의의(P<0.05).결론 여핵소폐관주현상상비,DEPI진단실험성급성폐전새유경고적민감도화특이도.
Objective To explore the clinical value of dual-energy CT lung perfusion imaging and perfusion scintigraphy in acute pulmonary embolism (PE) rabbit models. Methods Acute PE models were established in 20 rabbits with femoral vein injection of sponge as embolus materials, and 4 rabbits were injected saline as control group. Two hours after embolization, dual-energy CT and perfusion scintigraphy imaging were performed respectively. Taking the pathologicall findings as the reference standards, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of both imaging methods were compared. CT values and enhancement degree (overlay value) of the embolic areas and normal pulmonary parenchyma were measured in DEPI image after embolization. Results Normal lung was color-coded as homogeneously yellowish red, perfusion scintigraphy displayed rarefaction or absence. The sensitivity, specificity, PPV, NPV of DEPI was 100%, 97.50%, 95.24%, 100%, and of perfusion scintigraphy was 67.50%, 81.25%, 64.29%, 83.33%, respectively. Increased CT values and overlay values of embolism areas in DEPI images were lower than those of normal pulmonary parenchyma (P<0.05). Conclusion DEPI has higher sensitivity and specificity than perfusion scintigraphy for detection of pulmonary emboli in an acute PE rabbit models.
