中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2009年
2期
85-87,102
,共4页
直肠癌%VEGF-D%uPA
直腸癌%VEGF-D%uPA
직장암%VEGF-D%uPA
Rectal Neoplasm or Carcinoma%Vascular Endothelial Growth Factor D%Urinary Plas-minogen Activator
目的 探讨血管内皮生长因子一D(VEGF-D)和尿激酶型纤维蛋白酶原激活剂(uPA)在直肠癌中的表达特点及临床意义.方法 分别应用免疫组化SP法、Western blot法检测30例直肠癌组织及相应正常组织的VEGF-D和uPA的表达特点,分析其与l临床病理分期的关系.结果 VEGF-D和uPA在肿瘤组织和正常组织中均有表达,主要表达于胞浆,胞核也有.在肿瘤组织中的表达明显高于正常组织(P<0.01).VEGF-D或uPA的表达活性在Dukes C+D期明显高于A+B期(JP<0.01),在有淋巴结转移组和远处转移组的表达高于相应无转移组(P<0.05、P<0.01),随着肿瘤组织分化程度的增高活性依次降低(P<0.05).结论 VEGF-D和uPA在肿瘤组织中的高表达可能在肿瘤的发生发展过程中扮演重要角色.
目的 探討血管內皮生長因子一D(VEGF-D)和尿激酶型纖維蛋白酶原激活劑(uPA)在直腸癌中的錶達特點及臨床意義.方法 分彆應用免疫組化SP法、Western blot法檢測30例直腸癌組織及相應正常組織的VEGF-D和uPA的錶達特點,分析其與l臨床病理分期的關繫.結果 VEGF-D和uPA在腫瘤組織和正常組織中均有錶達,主要錶達于胞漿,胞覈也有.在腫瘤組織中的錶達明顯高于正常組織(P<0.01).VEGF-D或uPA的錶達活性在Dukes C+D期明顯高于A+B期(JP<0.01),在有淋巴結轉移組和遠處轉移組的錶達高于相應無轉移組(P<0.05、P<0.01),隨著腫瘤組織分化程度的增高活性依次降低(P<0.05).結論 VEGF-D和uPA在腫瘤組織中的高錶達可能在腫瘤的髮生髮展過程中扮縯重要角色.
목적 탐토혈관내피생장인자일D(VEGF-D)화뇨격매형섬유단백매원격활제(uPA)재직장암중적표체특점급림상의의.방법 분별응용면역조화SP법、Western blot법검측30례직장암조직급상응정상조직적VEGF-D화uPA적표체특점,분석기여l림상병리분기적관계.결과 VEGF-D화uPA재종류조직화정상조직중균유표체,주요표체우포장,포핵야유.재종류조직중적표체명현고우정상조직(P<0.01).VEGF-D혹uPA적표체활성재Dukes C+D기명현고우A+B기(JP<0.01),재유림파결전이조화원처전이조적표체고우상응무전이조(P<0.05、P<0.01),수착종류조직분화정도적증고활성의차강저(P<0.05).결론 VEGF-D화uPA재종류조직중적고표체가능재종류적발생발전과정중분연중요각색.
Objective To explore the expression of endothelial growth factor-D (VEGF-D) and uroki-nase-type plasminogen activator(uPA) in rectal carcinoma and to reveal their correlation to the tumor invasion and metastasis.Methods The expression of VEGF-D and uPA in 30 cases with rectal carcinoma and normal tissue was detected by immunohistochemistry and Western blot.Results The expression of VEGF-D and uPA was de-tected both in tumor tissue and normal tissue, but significantly higher in tumor tissue (P < 0.01), they expressed mostly in endochylema.The expression of VEGF-D or uPA was significantly higher in Dukes' stage C + D than that in Dukes' stage A + B(P <0.01), was also higher in tissues with lymph node metastasis or distant metasta-sis than those without metastasis(P <0.05 ,P <0.01).They were found to be lower in cancer tissue along with the differentiation degree increase(P < 0.05) .Condnsions The overexpression of VEGF-D and uPA in rectal carcinoma may play an important part in the tumorigenesis and progression of rectal carcinoma.
