CAJ | 학술논문

常用的肿瘤检测标志物敏感性低,特异性差,无法实现早期诊断目的,而肿瘤相关抗原的自身抗体能在肿瘤无症状阶段被检测到,因此可作为肿瘤早期诊断的生物标志物.由于自身抗体能在血清中检测到,所以能作为一种方便的非侵入性方法对肿瘤进行筛选.具有高度敏感性和特异性的自身抗体谱的发现,将有助于改善对肿瘤患者的诊断和预测.
상용적종류검측표지물민감성저,특이성차,무법실현조기진단목적,이종류상관항원적자신항체능재종류무증상계단피검측도,인차가작위종류조기진단적생물표지물.유우자신항체능재혈청중검측도,소이능작위일충방편적비침입성방법대종류진행사선.구유고도민감성화특이성적자신항체보적발현,장유조우개선대종류환자적진단화예측.
At present,the commonly used tumor markers,with low sensitivity and low specificity,can 't achieve the purpose of early diagnosis.However,autoantibodies against tumox-associated antigens have been detected in the asymptomatic stage of cancer and thus can serve as biomarkers for early cancer diagnosis.Moreover,due to autoantibodies are found in sera,they can he screened easily using a noninvasive approach.The discovery of panels of autoantibodies with high sensitivity and specificity will help to improve the diagnostic and prognostic for the patients with cancer.