中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
18期
2497-2499
,共3页
幽门螺旋杆菌%特发性血小板减少性紫癜
幽門螺鏇桿菌%特髮性血小闆減少性紫癜
유문라선간균%특발성혈소판감소성자전
Helicobacter pylori%Idiopathie thrombocytopenic purpur
目的 探讨抗幽门螺杆菌(HP)在特发性血小板减少性紫癜(ITP)治疗中的作用。方法 145例HP阳性ITP患者根据血小板计数分为血小板小于50 × 109/L及血小板大于50×109/L两组。血小板小于50×109/L HP阳性患者95例，按人院顺序随机分为联合治疗组与单用糖皮质激素组。联合治疗组给予根除HP及糖皮质激素治疗，单用糖皮质激素组未给予根除HP治疗，其余治疗同联合治疗组。血小板大于50×109/L HP阳性、无明显出血征象者50例，按入院顺序随机分为抗HP治疗组与对照组。抗HP治疗组进行单纯正规抗HP治疗，对照组未用任何药物治疗，定期复查血常规。结果 联合治疗组总有效率(92％)明显高于单用糖皮质激素治疗组(75％)(X2＝5.01，P＜0.05)，2年内复发率(19％)明显低于单用糖皮质激素组(49％)(X2＝9.69，P＜0.01)。单纯根除HP治疗对ITP患者有一定疗效。结论 根除HP是合并HP感染的ITP患者行之有效的治疗方法。
目的 探討抗幽門螺桿菌(HP)在特髮性血小闆減少性紫癜(ITP)治療中的作用。方法 145例HP暘性ITP患者根據血小闆計數分為血小闆小于50 × 109/L及血小闆大于50×109/L兩組。血小闆小于50×109/L HP暘性患者95例，按人院順序隨機分為聯閤治療組與單用糖皮質激素組。聯閤治療組給予根除HP及糖皮質激素治療，單用糖皮質激素組未給予根除HP治療，其餘治療同聯閤治療組。血小闆大于50×109/L HP暘性、無明顯齣血徵象者50例，按入院順序隨機分為抗HP治療組與對照組。抗HP治療組進行單純正規抗HP治療，對照組未用任何藥物治療，定期複查血常規。結果 聯閤治療組總有效率(92％)明顯高于單用糖皮質激素治療組(75％)(X2＝5.01，P＜0.05)，2年內複髮率(19％)明顯低于單用糖皮質激素組(49％)(X2＝9.69，P＜0.01)。單純根除HP治療對ITP患者有一定療效。結論 根除HP是閤併HP感染的ITP患者行之有效的治療方法。
목적 탐토항유문라간균(HP)재특발성혈소판감소성자전(ITP)치료중적작용。방법 145례HP양성ITP환자근거혈소판계수분위혈소판소우50 × 109/L급혈소판대우50×109/L량조。혈소판소우50×109/L HP양성환자95례，안인원순서수궤분위연합치료조여단용당피질격소조。연합치료조급여근제HP급당피질격소치료，단용당피질격소조미급여근제HP치료，기여치료동연합치료조。혈소판대우50×109/L HP양성、무명현출혈정상자50례，안입원순서수궤분위항HP치료조여대조조。항HP치료조진행단순정규항HP치료，대조조미용임하약물치료，정기복사혈상규。결과 연합치료조총유효솔(92％)명현고우단용당피질격소치료조(75％)(X2＝5.01，P＜0.05)，2년내복발솔(19％)명현저우단용당피질격소조(49％)(X2＝9.69，P＜0.01)。단순근제HP치료대ITP환자유일정료효。결론 근제HP시합병HP감염적ITP환자행지유효적치료방법。
Objective To investigate clinical effect of eradication of helicobacter pylori in patients with idiopathic thrombocytopenic purpura(ITP). Methods 145 cases with HP-positive ITP paitients were divided into two groups( platelet counts results ＜ 50 × 109/L and platelet counts results ＞ 50 × 109/L). 95 cases with platelet counts ＜50 × 109/L were divided into two groups and treated with prednisone and Hp eradication(48 cases) or with prednisone without Hp eradication(47 cases). 95 cases with platelet counts ＞ 50 × 109/L were divided into two groups and treated with Hp eradication 25 cases)or follow-up without any treatment(25 cases). Results The total effective rate in group treated with prednisone and Hp eradication was significantly higher than that in group with prednisone without Hp eradication( 92％ vd 75％, x2 ＝ 5.01 ,P ＜ 0.05 ). The recurrence rate in two year in group treated with prednisone and Hp eradication was significantly lower than that in group with prednisone without Hp eradication( 19％ vs 49％,x2 ＝ 9. 69, P ＜ 0. 01 ). HP eradicatiaon single can improve platelet counts in HP-positive ITP paitients.Conclusion The detection and eradication of H pylori infection should be considered in patients with ITP. H. pylori eradication could be used for initial treatment in HP-positive ITP paitients.
