CAJ | 학술논문

目的观察比索洛尔治疗80岁以上慢性心力衰竭患者的疗效和安全性.方法选择老年慢性心力衰竭患者108例,老年组(60～ 79岁)58例,高龄组(80岁及以上)50例,均按照指南给予优化药物治疗,β受体阻滞剂均选用比索洛尔,观察两组患者治疗前后心脏结构、功能的改变以及不良反应.结果治疗后两组左室射血分数较治疗前明显改善,老年组提高5％,高龄组提高4％,两组治疗后左室射血分数改善程度组内比较差异均有统计学意义(P＜0.01).两组治疗后心力衰竭症状均较治疗前改善,NYHA分级两组治疗前后组内比较差异有统计学意义(P＜0.01).不良事件发生率老年组和高龄组分别为38％和46％,组间比较差异无统计学意义(P＞0.05).结论比索洛尔治疗80岁以上慢性心力衰竭患者安全、有效.
목적 관찰비색락이치료80세이상만성심력쇠갈환자적료효화안전성.방법 선택노년만성심력쇠갈환자108례,노년조(60～ 79세)58례,고령조(80세급이상)50례,균안조지남급여우화약물치료,β수체조체제균선용비색락이,관찰량조환자치료전후심장결구、공능적개변이급불량반응.결과 치료후량조좌실사혈분수교치료전명현개선,노년조제고5％,고령조제고4％,량조치료후좌실사혈분수개선정도조내비교차이균유통계학의의(P＜0.01).량조치료후심력쇠갈증상균교치료전개선,NYHA분급량조치료전후조내비교차이유통계학의의(P＜0.01).불량사건발생솔노년조화고령조분별위38％화46％,조간비교차이무통계학의의(P＞0.05).결론 비색락이치료80세이상만성심력쇠갈환자안전、유효.
Objective To observe the efficacy and safety of bisoprolol on more than 80-year-old patients with chronic heart failure (CHF).Methods One hundred and eight old patients with chronic heart failure were involved in the study and were divided into the elder group( age ＞ 60 and ≤79,n =58)and the very elder group ( age ≥ 80 years,n =50).All patients were treated with optimal pharmacotherapy according to guideline recommendations,bisoprolol was given to all patients as β-blocker,changes of heart size,cardiac function and adverse events were observed.Results The LVEF improved significantly after treatment,5％ for elder group,and 4％ for very elder group.There was significantly difference between the two groups( P ＜ 0.01 ).The symptoms of chronic heart failure in both groups were improved,there were differences between before and after treatment (P ＜ 0.01 ).No significant difference was found on adverse events between the elder group (38％) and the very elder group (46％).Conclusions Bisoprolol is safe and effective for treating more than 80-year-old patients with chronic heart failure.