中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2012年
3期
192-195
,共4页
李忠武%田萌萌%武莹%孙宇%冯国双%游伟程%李吉友%赵爱莲
李忠武%田萌萌%武瑩%孫宇%馮國雙%遊偉程%李吉友%趙愛蓮
리충무%전맹맹%무형%손우%풍국쌍%유위정%리길우%조애련
细胞间黏附分子1%基因多态性%胃异型增生%胃炎%萎缩性
細胞間黏附分子1%基因多態性%胃異型增生%胃炎%萎縮性
세포간점부분자1%기인다태성%위이형증생%위염%위축성
Intercellular adhesion molecule-1%Gene polymorphism%Gastric dysplasia%Gastritis,atrophic
目的 研究细胞间黏附分子1( ICAM-1 )469K/E基因多态性对慢性萎缩性胃炎和异型增生发病危险性的影响.方法 采用多聚酶链式反应扩增产物直接测序方法检测中国北方胃癌高发区山东临朐县一组研究对象(共372例)ICAM-1基因469K/E位点的多态性.在研究计划开始时,所有研究对象的胃镜活检病理均表现为正常或浅表性胃炎,根据5年后的随访结果将研究对象分为非进展组(随访诊断仍为正常或浅表性胃炎,137例)、进展Ⅰ组(随访诊断为重度萎缩性胃炎,194例)和进展Ⅱ组(随访诊断为低级别异型增生,41例).结果 372例研究对象中,ICAM-1基因469位点KK、KE和EE基因型的分布频率分别为50.5％、39.2％和10.2％.进展Ⅰ组与非进展组间ICAM-1469K/E基因多态性的差异无统计学意义(P＞0.05).进展Ⅱ组KK基因型的分布频率(68.3％)显著高于非进展组(49.6％,P=0.035)和进展Ⅰ组(47.4％,P=0.015).携带ICAM-1 469 KK基因型的个体,其胃黏膜由正常或浅表性胃炎进展为低级别异型增生的危险性显著增加( OR =2.21,95％CI为1.10～4.42).结论 中国北方胃癌高发区人群中ICAM-1 469K/E基因多态性明显增加胃黏膜低级别异型增生的发病风险,但与重度萎缩性胃炎的发病无关.
目的 研究細胞間黏附分子1( ICAM-1 )469K/E基因多態性對慢性萎縮性胃炎和異型增生髮病危險性的影響.方法 採用多聚酶鏈式反應擴增產物直接測序方法檢測中國北方胃癌高髮區山東臨朐縣一組研究對象(共372例)ICAM-1基因469K/E位點的多態性.在研究計劃開始時,所有研究對象的胃鏡活檢病理均錶現為正常或淺錶性胃炎,根據5年後的隨訪結果將研究對象分為非進展組(隨訪診斷仍為正常或淺錶性胃炎,137例)、進展Ⅰ組(隨訪診斷為重度萎縮性胃炎,194例)和進展Ⅱ組(隨訪診斷為低級彆異型增生,41例).結果 372例研究對象中,ICAM-1基因469位點KK、KE和EE基因型的分佈頻率分彆為50.5％、39.2％和10.2％.進展Ⅰ組與非進展組間ICAM-1469K/E基因多態性的差異無統計學意義(P＞0.05).進展Ⅱ組KK基因型的分佈頻率(68.3％)顯著高于非進展組(49.6％,P=0.035)和進展Ⅰ組(47.4％,P=0.015).攜帶ICAM-1 469 KK基因型的箇體,其胃黏膜由正常或淺錶性胃炎進展為低級彆異型增生的危險性顯著增加( OR =2.21,95％CI為1.10～4.42).結論 中國北方胃癌高髮區人群中ICAM-1 469K/E基因多態性明顯增加胃黏膜低級彆異型增生的髮病風險,但與重度萎縮性胃炎的髮病無關.
목적 연구세포간점부분자1( ICAM-1 )469K/E기인다태성대만성위축성위염화이형증생발병위험성적영향.방법 채용다취매련식반응확증산물직접측서방법검측중국북방위암고발구산동림구현일조연구대상(공372례)ICAM-1기인469K/E위점적다태성.재연구계화개시시,소유연구대상적위경활검병리균표현위정상혹천표성위염,근거5년후적수방결과장연구대상분위비진전조(수방진단잉위정상혹천표성위염,137례)、진전Ⅰ조(수방진단위중도위축성위염,194례)화진전Ⅱ조(수방진단위저급별이형증생,41례).결과 372례연구대상중,ICAM-1기인469위점KK、KE화EE기인형적분포빈솔분별위50.5％、39.2％화10.2％.진전Ⅰ조여비진전조간ICAM-1469K/E기인다태성적차이무통계학의의(P＞0.05).진전Ⅱ조KK기인형적분포빈솔(68.3％)현저고우비진전조(49.6％,P=0.035)화진전Ⅰ조(47.4％,P=0.015).휴대ICAM-1 469 KK기인형적개체,기위점막유정상혹천표성위염진전위저급별이형증생적위험성현저증가( OR =2.21,95％CI위1.10～4.42).결론 중국북방위암고발구인군중ICAM-1 469K/E기인다태성명현증가위점막저급별이형증생적발병풍험,단여중도위축성위염적발병무관.
Objective To investigate the influence of ICAM-1 469K/E gene polymorphisms on the risk of atrophic gastritis and dysplasia.Methods The ICAM-1 469K/E gene polymorphisms in a total of 372 subjects were detected by polymerase chain reaction-direct sequencing.All of the subjects were from Linqu County,a high risk area of gastric cancer in Shandong Province of northern China.All cases were initially diagnosed as normal or superficial gastritis at the beginning of this study.After a 5-year follow-up,the cases were subdivided into no progression group ( no histological progression,n =137 ),progression group Ⅰ (progressed to severe chronic atrophic gastritis,n =194) and progression group Ⅱ (progressed to low-grade dysplasia,n =41 ).Results In all 372 subjects,the frequencies of KK,KE or EE genotype of ICAM-1 K469E were 50.5％,39.2％ and 10.2％,respectively.No significant differences were observed in the ICAM-1 469K/E genotype frequencies between the progression group Ⅰ and no progression group( P ＞0.05 ).The frequencies of KK genotype (68.3％) were significantly higher in the progression group Ⅱ than in the no progression group (49.6％,P =0.035),and also than in the progression group Ⅰ (47.4％,P =0.015).An increased risk of the progressing to dysplasia from normal or superficial gastritis was found in the individuals with ICAM-1 469KK genotype [ odds ratio (OR) =2.21,95％ CI,1.10-4.42 ].Conclusion ICAM-1 469K/E gene polymorphisms are significantly associated with the risk of gastric low-grade dysplasia,but not related with severe chronic atrophic gastritis in a population with high risk of gastric cancer in Linqu County,Shandong Province,China.
