CAJ | 학술논문

谷氨酸是中枢神经系统主要的快速兴奋性递质.AMPA受体和海人藻酸受体主要参与突触传递,而NMDA受体主要参与突触可塑性.基因操作的方法增强NMDA受体的功能,可以增强动物在正常生理状态下的学习能力,及在组织损伤情况下的反应敏感性.NMDA受体参与生理功能的主要机制是长时程增强(long-term potentiation,LTP).我们的研究表明,NMDA受体不仅参与刺激前扣带皮层的第五层细胞或刺激白质诱导的突触反应,而且参与在胞体施加去极化跃阶电流诱导的动作电位的发放.钙-钙调蛋白敏感的腺苷酸环化酶1(adenylyl cyclase 1,AC1)和cAMP信号通路可能介导了这些反应.由于扣带皮层神经元在伤害性刺激和痛中发挥重要作用,我们的结果为前脑NMDA受体参与突触传递和动作电位发放,以及与前脑相关的行为,如感受伤害性刺激和痛,提供了一个新的机制.
곡안산시중추신경계통주요적쾌속흥강성체질.AMPA수체화해인조산수체주요삼여돌촉전체,이NMDA수체주요삼여돌촉가소성.기인조작적방법증강NMDA수체적공능,가이증강동물재정상생리상태하적학습능력,급재조직손상정황하적반응민감성.NMDA수체삼여생리공능적주요궤제시장시정증강(long-term potentiation,LTP).아문적연구표명,NMDA수체불부삼여자격전구대피층적제오층세포혹자격백질유도적돌촉반응,이차삼여재포체시가거겁화약계전류유도적동작전위적발방.개-개조단백민감적선감산배화매1(adenylyl cyclase 1,AC1)화cAMP신호통로가능개도료저사반응.유우구대피층신경원재상해성자격화통중발휘중요작용,아문적결과위전뇌NMDA수체삼여돌촉전체화동작전위발방,이급여전뇌상관적행위,여감수상해성자격화통,제공료일개신적궤제.
Glutamate is the major fast excitatory transmitter in the central nervous system.While normal synaptic transmission is mediated byα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)and kainate receptors,N-methyl-D-aspartate(NMDA) receptors are thought to selectively contribute to plasticity.Genetically enhancing NMDA receptor functions enhances animal behavior in normal physiological learning and enhances their sensitivity in the case of tissue injury.One major mechanism for NMDA receptors is synaptic long-term potentiation(LTP).Here we present evidence that NMDA receptors not only contribute to normal synaptic responses induced by stimulation of local layer V or white matters,but also contribute to generation of action potentials induced by a depolarizing step applied to the soma.Calcium-calmodulin sensitive adenylyl cyclase 1 and cAMP signal pathways likely mediate these effects.Considering the importance of cingulate neurons in nociception and pain,our results provide a new mechanism for NMDA receptor contributing to neuronal synaptic transmission,spiking properties in forebrains,and possible forebrain-related behavioral nociceptive responses and pain.