国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2008年
7期
612-613,616
,共3页
高半胱氨酸%冠状动脉疾病%危险因素
高半胱氨痠%冠狀動脈疾病%危險因素
고반광안산%관상동맥질병%위험인소
Homocysteine%Coronary Disease%Risk Factors
目的 探讨血浆同型半胱氨酸(HCY)水平与冠心病(CHD)的关系.方法 采用循环酶法分别测定CHD患者(117例)及健康对照组(50例)血浆中HCY水平.CHD患者按不同临床类型分为稳定型心绞痛(SAP)组(35例)、不稳定型心绞痛(UAP)组(39例)和急性心肌梗死(AMI)组(43例);CHD患者根据冠状动脉造影术进一步分为1支病变组(31例)、2支病变组(40例)和3支病变组(46例).结果 1)CHD组血浆HCY水平明显高于健康对照组(P<0.01).2)不同临床类型的CHD患者,HCY水平显示AMI组>UAP组>SAP组,其中SAP组、UAP组、AMI组与健康对照组比较差异均有统计学意义(P<0.01),SAP组与UAP组、AMI组比较差异有统计学意义(P<0.01),UAP组与AMI组比较,差异有统计学意义(P<0.01).3)1、2、3支血管病变者血浆HCY浓度呈逐级增高趋势,1支与3支病变组、2支与3支病变组之间差异有统计学意义(P<0.01),1支与2支病变组之间差异无统计学意义(P>0.05).结论 CHD患者血浆HCY水平明显增高,冠状动脉病变支数越多,血浆HCY水平越高,提示HCY水平变化与CHD的发生、发展密切相关,是CHD的一个危险因素.
目的 探討血漿同型半胱氨痠(HCY)水平與冠心病(CHD)的關繫.方法 採用循環酶法分彆測定CHD患者(117例)及健康對照組(50例)血漿中HCY水平.CHD患者按不同臨床類型分為穩定型心絞痛(SAP)組(35例)、不穩定型心絞痛(UAP)組(39例)和急性心肌梗死(AMI)組(43例);CHD患者根據冠狀動脈造影術進一步分為1支病變組(31例)、2支病變組(40例)和3支病變組(46例).結果 1)CHD組血漿HCY水平明顯高于健康對照組(P<0.01).2)不同臨床類型的CHD患者,HCY水平顯示AMI組>UAP組>SAP組,其中SAP組、UAP組、AMI組與健康對照組比較差異均有統計學意義(P<0.01),SAP組與UAP組、AMI組比較差異有統計學意義(P<0.01),UAP組與AMI組比較,差異有統計學意義(P<0.01).3)1、2、3支血管病變者血漿HCY濃度呈逐級增高趨勢,1支與3支病變組、2支與3支病變組之間差異有統計學意義(P<0.01),1支與2支病變組之間差異無統計學意義(P>0.05).結論 CHD患者血漿HCY水平明顯增高,冠狀動脈病變支數越多,血漿HCY水平越高,提示HCY水平變化與CHD的髮生、髮展密切相關,是CHD的一箇危險因素.
목적 탐토혈장동형반광안산(HCY)수평여관심병(CHD)적관계.방법 채용순배매법분별측정CHD환자(117례)급건강대조조(50례)혈장중HCY수평.CHD환자안불동림상류형분위은정형심교통(SAP)조(35례)、불은정형심교통(UAP)조(39례)화급성심기경사(AMI)조(43례);CHD환자근거관상동맥조영술진일보분위1지병변조(31례)、2지병변조(40례)화3지병변조(46례).결과 1)CHD조혈장HCY수평명현고우건강대조조(P<0.01).2)불동림상류형적CHD환자,HCY수평현시AMI조>UAP조>SAP조,기중SAP조、UAP조、AMI조여건강대조조비교차이균유통계학의의(P<0.01),SAP조여UAP조、AMI조비교차이유통계학의의(P<0.01),UAP조여AMI조비교,차이유통계학의의(P<0.01).3)1、2、3지혈관병변자혈장HCY농도정축급증고추세,1지여3지병변조、2지여3지병변조지간차이유통계학의의(P<0.01),1지여2지병변조지간차이무통계학의의(P>0.05).결론 CHD환자혈장HCY수평명현증고,관상동맥병변지수월다,혈장HCY수평월고,제시HCY수평변화여CHD적발생、발전밀절상관,시CHD적일개위험인소.
Objective To investigate the correlation between plasma homoeysteine (HCY) level and coronary-heart disease (CHD). Methods 117 patients with coronary heart disease (CHD group) and 50 healthy controls (control group) were involved in the investigation. Plasma total HCY level was measured with enzymatic cycling assay. According to the clinical types, CHD cases were divide dinto stable angina pectoris (SAP) group (n = 35), unstable angina pectoris (UAP) group (n = 39) and acute myocardial infarction (AMI) group (n=43). Based on coronary angiography, the CHD cases were further divided into single-vessel (n = 31 ), double-vessel (n = 40) and triple-vessel (n = 46) groups. Results 1 ) Plasma HCY level was significantly higher in CHD group than that in control group (P<0. 01). 2) Plasma HCY level was associated with clinical types, higherst in AMI group, followed by that of UAP group, SAP group, healthy control group. There was statistical difference of HCY level between SAP group and UAP group, SAP group and AMI group, UAP group and AMI group (P<0. 01). 3) Plasma HCY level was gradually elevated in single-vessel, double-vessel and tri- ple-vessel group. There was statistical difference of HCY level between single-vessel group or double- vessel group and triple-vessel group (P<0.01). There was significant difference between single-vessel group and double-vessel group (P>0.05). Conclusion Plasma HCY level is elevated in patients with CHD, and elevated HCY is associated with increased number of stenotic coronary arteries. As a risk factor for CHD, HCY is closely associated with the occurrence and development of CHD.
