CAJ | 학술논문

目的探讨红景天口服液对雄性大鼠生殖功能的影响.方法取SD大鼠100只,雌雄各半,分别按照随机数字表法分成5组,各10只.①雄性大鼠的5组除空白对照组外,其余4组分别给予红景天口服液2.48 g/kg、7.48 g/kg、24.80 g/kg,男宝胶囊2.00 g/kg,2 次/d,连续48 d.然后与切除双侧卵巢后15 d的雌性大鼠50只按1∶1合笼进行交配,观察雄性大鼠的交配能力、睾酮水平、免疫器官的变化.②另取4周龄雄性SD大鼠40只分为空白对照组、模型对照组、红景天低剂量组、红景天高剂量组、甲睾酮组共5组,各8只.除空白对照组外,其余均切除双侧睾丸,分别给予红景天口服液0、2.48 g/kg、24.80 g/kg,甲睾酮2.00 mg/kg,2次/d,连续28 d,观察去势大鼠的雄性附属性器官的变化.结果 ①与空白对照组比较,红景天口服液高、中、低剂量组大鼠体内睾酮水平、脾脏指数和胸腺指数显著提高(P<0.05、P<0.01).②给药后去势大鼠的附性器官指数显著高于模型对照组(P<0.05).结论红景天口服液可提高雄性大鼠的生殖功能.
목적 탐토홍경천구복액대웅성대서생식공능적영향.방법 취SD대서100지,자웅각반,분별안조수궤수자표법분성5조,각10지.①웅성대서적5조제공백대조조외,기여4조분별급여홍경천구복액2.48 g/kg、7.48 g/kg、24.80 g/kg,남보효낭2.00 g/kg,2 차/d,련속48 d.연후여절제쌍측란소후15 d적자성대서50지안1∶1합롱진행교배,관찰웅성대서적교배능력、고동수평、면역기관적변화.②령취4주령웅성SD대서40지분위공백대조조、모형대조조、홍경천저제량조、홍경천고제량조、갑고동조공5조,각8지.제공백대조조외,기여균절제쌍측고환,분별급여홍경천구복액0、2.48 g/kg、24.80 g/kg,갑고동2.00 mg/kg,2차/d,련속28 d,관찰거세대서적웅성부속성기관적변화.결과 ①여공백대조조비교,홍경천구복액고、중、저제량조대서체내고동수평、비장지수화흉선지수현저제고(P<0.05、P<0.01).②급약후거세대서적부성기관지수현저고우모형대조조(P<0.05).결론 홍경천구복액가제고웅성대서적생식공능.
Objective To observe the action of Rhodiola Crenulate(RC) oral liquid reproduction function for the male rats. Methods 100 SD rats were randomly divided into 5 groups with equal gender number respectively. The male rats were given RC oral liquid (0, 2.48 g/kg, 7.48 g/kg, 24.80 g/kg) and Nanbao (2.00 g/kg)by oral twice a day for 48 d, respectively. Then the male rat was put into the same box in which the female rat whit two-side ovarys were excised for 15 d, respectively. The intercoursing ability,testosterone levels, and the weight of immune organs of the male rats were examined. 40 four-week-old rats were divided into 5 groups. Except for blank control, all rats's testis were excised. The castrated rats were treated with RC oral liquid (2.48 g/kg, 24.8 g/kg)and Methyltestosterone (2.00 mg/kg). The blank control group and model control group were given the same dose NS by oral twice a day for 28 d, respectively. The weight of accessory sex organs in castrated rats was observed. Results The level of testosterone and the organ coefficients of thymus and spleen in RC oral liquid groups were higher than blank control (P<0.05 or P<0.01).The weight of accessory sex organs of castrated rats in RC oral liquid groups were heavier than model control (P<0.05). Conclusion RC oral liquid can improve the reproduction function in male rats.