CAJ | 학술논문

目的探讨替米沙坦对高血压并不稳定型心绞痛患者血清脂联素(APN)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)表达的影响.方法将100例高血压并不稳定型心绞痛患者按数字表法随机分为替米沙坦组(50例)和氯沙坦组(50例),分别予以口服替米沙坦和氯沙坦治疗,均治疗8周.观察两组血压控制情况、血清APN、hs-CRP和TNF-α表达及治疗后心血管事件发生情况.结果两组治疗8周后均实现血压达标.治疗开始后,替米沙坦组APN升高较氯沙坦组快(P＜0.05),替米沙坦组hs-CRP、TNF-α水平降低亦均较氯沙坦组快(均P＜0.05).两组均随访4个月,替米沙坦组心血管事件发生率为10.0%(5/50),明显低于氯沙坦组的24.5%(12/49)(P＜0.05).结论替米沙坦对高血压并不稳定型心绞痛患者APN、hs-CRP、TNF-α表达的调节作用较氯沙坦更显著,更有利于降低此类患者的短期心血管事件发生率.
목적 탐토체미사탄대고혈압병불은정형심교통환자혈청지련소(APN)、초민C반응단백(hs-CRP)、종류배사인자(TNF-α)표체적영향.방법 장100례고혈압병불은정형심교통환자안수자표법수궤분위체미사탄조(50례)화록사탄조(50례),분별여이구복체미사탄화록사탄치료,균치료8주.관찰량조혈압공제정황、혈청APN、hs-CRP화TNF-α표체급치료후심혈관사건발생정황.결과 량조치료8주후균실현혈압체표.치료개시후,체미사탄조APN승고교록사탄조쾌(P＜0.05),체미사탄조hs-CRP、TNF-α수평강저역균교록사탄조쾌(균P＜0.05).량조균수방4개월,체미사탄조심혈관사건발생솔위10.0%(5/50),명현저우록사탄조적24.5%(12/49)(P＜0.05).결론 체미사탄대고혈압병불은정형심교통환자APN、hs-CRP、TNF-α표체적조절작용교록사탄경현저,경유리우강저차류환자적단기심혈관사건발생솔.
Objective To investigate the effect of telmisartan on the expression of APN,hs-CRP,TNF-α and the prognosis of hypertensive patients with unstable angina pectoris. Methods Totally 100 hypertensive patients with unstable angina pectoris were randomly divided into the telmisartan group(n =50) and the losartan group(n =50),each group with oral administration. The blood pressure controlled condition, APN, hs-CRP and TNF-α content changes and the occurrence of cardiovascular accident after treatment were observed in both two groups. Results In both groups, blood pressure returned to normal in 8 weeks,with no significant difference(P ＞ 0.05). After treatment,APN level in the telmisartan group increased faster than that in the losartan group(P ＜0.05) ,while the hs-CRP,TNF-αdecreased significantly(P ＜ 0.05). After 8 weeks, the occurrence of cardiovascular accident in the telmisartan and losartan groups was 10.0% (5/50) and 24. 5 % (12/49) respectively in the following 4 months (P ＜ 0.05). Conclusion Telmisartan has significant effect in regulating APN, hs-CRP, TNF-α expression in hypertensive patients with unstable angina pectoris, which is able to decrease the short-term occurrence of cardiovascular accident.