中国行为医学科学
中國行為醫學科學
중국행위의학과학
2008年
9期
814-815
,共2页
朱建中%蒋幸衍%张梓威%陆蘅
硃建中%蔣倖衍%張梓威%陸蘅
주건중%장행연%장재위%륙형
奎硫平%利培酮%催乳素%体质量%胰岛素抵抗%瘦素
奎硫平%利培酮%催乳素%體質量%胰島素牴抗%瘦素
규류평%리배동%최유소%체질량%이도소저항%수소
Quetiapine%Risperidon%Seroprolactin%Weight%Insulin resistance%Leptin
目的 探讨奎硫平与利培酮对血清催乳素的影响及催乳索与药物疗效、体质量、胰岛素抵抗之间的相互关系.方法 64例停药1月以上的精神分裂症患者分别服用奎硫平(n=31)与利培酮(n=33),治疗前及治疗后8周分别测定其空腹血清催乳素、瘦素、胰岛素、血糖水平,测身高与体质量,以体质量指数评定体脂情况,以胰岛素抵抗指数(HOMA-Insulin Resistance,HOMA-IR=空腹胰岛素×空腹血糖)评定胰岛素抵抗,以简明精神症状评定量表(BPRS)减分率评定药物疗效.结果 治疗8周后利培酮组血清催乳素明显增加[治疗前(487.54±426.04)mlU/L,治疗后(1632.50±1005.31)mlU/L,P=0.000].而奎硫平组催乳素浓度无明显改变[治疗前(531.47±420.91)mlU/L,治疗后(478.93±413.18)mlU/L,P=0.687].多因素逐步回归显示催乳素与性别及不同药物有关.结论 利培酮能增加血清催乳素水平,奎硫平对催乳素基本无影响,催乳素与药物疗效、体质量、瘦素及胰岛素抵抗等无直接联系.
目的 探討奎硫平與利培酮對血清催乳素的影響及催乳索與藥物療效、體質量、胰島素牴抗之間的相互關繫.方法 64例停藥1月以上的精神分裂癥患者分彆服用奎硫平(n=31)與利培酮(n=33),治療前及治療後8週分彆測定其空腹血清催乳素、瘦素、胰島素、血糖水平,測身高與體質量,以體質量指數評定體脂情況,以胰島素牴抗指數(HOMA-Insulin Resistance,HOMA-IR=空腹胰島素×空腹血糖)評定胰島素牴抗,以簡明精神癥狀評定量錶(BPRS)減分率評定藥物療效.結果 治療8週後利培酮組血清催乳素明顯增加[治療前(487.54±426.04)mlU/L,治療後(1632.50±1005.31)mlU/L,P=0.000].而奎硫平組催乳素濃度無明顯改變[治療前(531.47±420.91)mlU/L,治療後(478.93±413.18)mlU/L,P=0.687].多因素逐步迴歸顯示催乳素與性彆及不同藥物有關.結論 利培酮能增加血清催乳素水平,奎硫平對催乳素基本無影響,催乳素與藥物療效、體質量、瘦素及胰島素牴抗等無直接聯繫.
목적 탐토규류평여리배동대혈청최유소적영향급최유색여약물료효、체질량、이도소저항지간적상호관계.방법 64례정약1월이상적정신분렬증환자분별복용규류평(n=31)여리배동(n=33),치료전급치료후8주분별측정기공복혈청최유소、수소、이도소、혈당수평,측신고여체질량,이체질량지수평정체지정황,이이도소저항지수(HOMA-Insulin Resistance,HOMA-IR=공복이도소×공복혈당)평정이도소저항,이간명정신증상평정량표(BPRS)감분솔평정약물료효.결과 치료8주후리배동조혈청최유소명현증가[치료전(487.54±426.04)mlU/L,치료후(1632.50±1005.31)mlU/L,P=0.000].이규류평조최유소농도무명현개변[치료전(531.47±420.91)mlU/L,치료후(478.93±413.18)mlU/L,P=0.687].다인소축보회귀현시최유소여성별급불동약물유관.결론 리배동능증가혈청최유소수평,규류평대최유소기본무영향,최유소여약물료효、체질량、수소급이도소저항등무직접련계.
Objective To study the influence of quetiapine and risperidon on semprolaetin and the relationship between semprolactin and drug efficiency.body weight and insulin resistance.Method 64 cases with schizophreniac which stopped taking drugs for more than 1 month were given quetiapine(n=31)and risperidon(n=33)respectively.Their fasting seropmlactin,leptin,insulin,blood sugar level,body height and weight were measured before and 8 weeks after treatment.To evaluate body lipid by BMI[BMI=weight/height2(kg/m2)].Insulin resistance was evaluated by insulin resistance index(HOMA-insulin resistance,HOMA-IR=fasting insulin×fasting blood snger)and drug efficiency Was evaluated by BPRS scale.Results Seroprolactin of risperidon group obviously increased after treatment for 8 weeks than before treatment[(487.54±426.04)mlU/L vs(1632.50±1005.31)mlU/L,P=0.000],but seropmlactin of quetiapine group had no obvious changes[before treatment vs after treatment(531.47±420.91)mlU/L vs(478.93±413.18)mlU/L,P=0.687].Regression of multiple factot's showed that seroprolactin was associated with sex and different drugs.Conclusion Risperidon can increase the level of seroprolactin,quetiapine has little effect on seroprolactin.There is no direct correlation among seroprolactin,drug efficiency,weight,leptin and insulin resistance.
