中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2009年
5期
349-353
,共5页
卢建溪%钱师宇%舒欣%李刚
盧建溪%錢師宇%舒訢%李剛
로건계%전사우%서흔%리강
肝炎%乙型%慢性%肝炎表面抗原%乙型%肝炎病毒%乙型%复制水平%核苷类似物
肝炎%乙型%慢性%肝炎錶麵抗原%乙型%肝炎病毒%乙型%複製水平%覈苷類似物
간염%을형%만성%간염표면항원%을형%간염병독%을형%복제수평%핵감유사물
Hepatitis B%chronic%Hepatitis B surface antigens%Hepatitis B virus%Replication levels%Nucleoside analogue
目的 监测核苷类似物治疗慢性乙犁肝炎(CHB)的过程中HBsAg及HBV DNA水平的动态变化,并探讨HBsAg滴度与HBV DNA复制水平的相关性.方法 选取57例拉米夫定(LAM)、20例阿德福韦(ADV)抗病毒治疗2年以及23例未使用核苷类似物治疗的CHB患者,所有患者均未进行其它抗病毒药物治疗.于不同时间点采集血清标本,动态监测HBsAg及HBV DNA水平,并分析两者之间的相关性.结果 (1)57例LAM抗病毒治疗的CHB患者中,20例有效应答后出现病毒反弹的患者,在HBV DNA发生剧烈变化的4个时间点.未观察到HBsAg滴度随HBV DNA复制水平的一致变化,无相关性(P>0.05);37例应答良好的患者,可观察到HBsAg水平随HBV DNA复制水平的一致变化,呈正相关(r=0.71,P<0.05).(2)20例ADV抗病毒治疗的CHB患者中,7例有效应答后出现病毒反弹的患者,未观察到HBsAg随HBV DNA水平的一致变化,无相关性(P>0.05);13例应答良好的患者,可观察到HBsAg随HBV DNA复制水平的一致变化,呈正相关(r=0.73,P<0.05).结论 核苷类似物治疗CHB的过程中,对核苷类似物抗病毒治疗有良好应答的患者,HBsAg滴度在一定程度上能反映HBV DNA复制水平,HBsAg滴度与HBV DNA复制水平有相关性.
目的 鑑測覈苷類似物治療慢性乙犛肝炎(CHB)的過程中HBsAg及HBV DNA水平的動態變化,併探討HBsAg滴度與HBV DNA複製水平的相關性.方法 選取57例拉米伕定(LAM)、20例阿德福韋(ADV)抗病毒治療2年以及23例未使用覈苷類似物治療的CHB患者,所有患者均未進行其它抗病毒藥物治療.于不同時間點採集血清標本,動態鑑測HBsAg及HBV DNA水平,併分析兩者之間的相關性.結果 (1)57例LAM抗病毒治療的CHB患者中,20例有效應答後齣現病毒反彈的患者,在HBV DNA髮生劇烈變化的4箇時間點.未觀察到HBsAg滴度隨HBV DNA複製水平的一緻變化,無相關性(P>0.05);37例應答良好的患者,可觀察到HBsAg水平隨HBV DNA複製水平的一緻變化,呈正相關(r=0.71,P<0.05).(2)20例ADV抗病毒治療的CHB患者中,7例有效應答後齣現病毒反彈的患者,未觀察到HBsAg隨HBV DNA水平的一緻變化,無相關性(P>0.05);13例應答良好的患者,可觀察到HBsAg隨HBV DNA複製水平的一緻變化,呈正相關(r=0.73,P<0.05).結論 覈苷類似物治療CHB的過程中,對覈苷類似物抗病毒治療有良好應答的患者,HBsAg滴度在一定程度上能反映HBV DNA複製水平,HBsAg滴度與HBV DNA複製水平有相關性.
목적 감측핵감유사물치료만성을리간염(CHB)적과정중HBsAg급HBV DNA수평적동태변화,병탐토HBsAg적도여HBV DNA복제수평적상관성.방법 선취57례랍미부정(LAM)、20례아덕복위(ADV)항병독치료2년이급23례미사용핵감유사물치료적CHB환자,소유환자균미진행기타항병독약물치료.우불동시간점채집혈청표본,동태감측HBsAg급HBV DNA수평,병분석량자지간적상관성.결과 (1)57례LAM항병독치료적CHB환자중,20례유효응답후출현병독반탄적환자,재HBV DNA발생극렬변화적4개시간점.미관찰도HBsAg적도수HBV DNA복제수평적일치변화,무상관성(P>0.05);37례응답량호적환자,가관찰도HBsAg수평수HBV DNA복제수평적일치변화,정정상관(r=0.71,P<0.05).(2)20례ADV항병독치료적CHB환자중,7례유효응답후출현병독반탄적환자,미관찰도HBsAg수HBV DNA수평적일치변화,무상관성(P>0.05);13례응답량호적환자,가관찰도HBsAg수HBV DNA복제수평적일치변화,정정상관(r=0.73,P<0.05).결론 핵감유사물치료CHB적과정중,대핵감유사물항병독치료유량호응답적환자,HBsAg적도재일정정도상능반영HBV DNA복제수평,HBsAg적도여HBV DNA복제수평유상관성.
Objective To investigate the correlation between hepatitis B surface antigen (HBsAg) level and hepatitis B virus (HBV) DNA replication level in chronic hepatitis B (CHB) patients treated with nucleoside analogues. Methods Of 100 CHB patients, 57 were treated with lamivudine for 2 years, 20 with adefovir dipivoxil for 2 years and 23 were nucleoside-naive. Any other antiviral medication was not performed in all patients. Serum samples were collected at different time points. HBV DNA was measured with real-time polymerase chain reaction (PCR) and HBsAg was quantified with an automated chemiluminescent microparticle immunoassay. Correlation between HBV DNA and HBsAg were analyzed. Results (1)Among the 57 lamivudine-treated CHB patients, 20 who showed viral rebound after a good response were found with drastic changes in HBV DNA level at 4 time points not accompanied by correlated trends in HBsAg (P>0.05), and 37 who maintained a good response throughout the study were found with positively correlated changes in HBsAg and HBV DNA level (r=0.71, P< 0.05). (2) In the 20 adefovir-treated patients, correlated changes in HBV DNA duplication level and HBsAg were observed in 13 patients who maintained a good response throughout the study (r=0.73, P<0.05) but not in the other 7 who showed viral rebound after a good response (P>0.05). Conclusion During nucleoside analogue treatment of CHB, HBsAg titer may somewhat reflex the HBV DNA duplication level with good correlation among those who respond well to the therapy.
