CAJ | 학술논문

采用24 h动态心电图检测58例2型糖尿病伴下肢神经病变组、59例2型糖尿病不伴下肢神经病变组(非下肢神经病变组)和50例对照组的心率变异性,比较其频域参数的水平及昼夜间的变化.结果显示非下肢神经病变组、下肢神经病变组较对照组频域指标减小,平均心率增加;昼夜间比较在对照组差异有统计学意义,在非下肢神经病变组昼夜节律发生改变,在下肢神经病变组昼夜节律消失.提示糖尿病不伴和伴下肢神经病变均存在自主神经功能受损,后者受损更明显.
채용24 h동태심전도검측58례2형당뇨병반하지신경병변조、59례2형당뇨병불반하지신경병변조(비하지신경병변조)화50례대조조적심솔변이성,비교기빈역삼수적수평급주야간적변화.결과 현시비하지신경병변조、하지신경병변조교대조조빈역지표감소,평균심솔증가;주야간비교재대조조차이유통계학의의,재비하지신경병변조주야절률발생개변,재하지신경병변조주야절률소실.제시당뇨병불반화반하지신경병변균존재자주신경공능수손,후자수손경명현.
Heart rate variability(HRV)analysis and its circadian rhythm(CR)were determined in 58patients with type 2 diabetes mellitus with lower extremity neuropathy(diabetic neuropathy group), 59 patients with type 2 diabetes mellitus without lower extremity neuropathy(diabetes group), and 50 healthy controls according to 24-hour Holter recording. Frequency domain parameters of HRV were significantly decreased in both diabetes groups. Frequency domain parameter of HRV in healthy controls,and daytime/nighttime difference were statistically significant. CR of HRV was changed in diabetes group and disappeared in diabetic neuropathy group. Impaired and seriously impaired autonomic nervous function developed in type 2 diabetes mellitus without and with lower extremity neuropathy respectively.