中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
5期
29-30,33
,共3页
阿托伐他汀%阿尔茨海默病%降胆固醇治疗
阿託伐他汀%阿爾茨海默病%降膽固醇治療
아탁벌타정%아이자해묵병%강담고순치료
Atovastatin%Alzheimer's disease%Cholesterol-lowering treatment
目的 观察阿托伐他汀对轻、中度阿尔茨海默病高胆固醇患者有无神经保护作用.方法 选择轻度、中度阿尔茨海默病合并高胆固醇患者40例,根据就诊次序随机分为治疗组和对照组.治疗组每晚服阿托伐他汀20 mg,对照组给予安慰剂治疗.比较两组治疗前及治疗第8、20周的简易智能状态量表、临床痴呆评定量表和日常生活自理量表评分.结果 治疗8周时治疗组、对照组各项量表评分与治疗前比较差异无统计学意义(P>0.05);治疗20周时治疗组各项量表评分与治疗前有显著改善(P<0.01),与对照组比较差异有统计学意义(P<0.05).结论 阿托伐他汀对轻、中度阿尔茨海默病合并高胆固醇者有一定脑保护作用.
目的 觀察阿託伐他汀對輕、中度阿爾茨海默病高膽固醇患者有無神經保護作用.方法 選擇輕度、中度阿爾茨海默病閤併高膽固醇患者40例,根據就診次序隨機分為治療組和對照組.治療組每晚服阿託伐他汀20 mg,對照組給予安慰劑治療.比較兩組治療前及治療第8、20週的簡易智能狀態量錶、臨床癡呆評定量錶和日常生活自理量錶評分.結果 治療8週時治療組、對照組各項量錶評分與治療前比較差異無統計學意義(P>0.05);治療20週時治療組各項量錶評分與治療前有顯著改善(P<0.01),與對照組比較差異有統計學意義(P<0.05).結論 阿託伐他汀對輕、中度阿爾茨海默病閤併高膽固醇者有一定腦保護作用.
목적 관찰아탁벌타정대경、중도아이자해묵병고담고순환자유무신경보호작용.방법 선택경도、중도아이자해묵병합병고담고순환자40례,근거취진차서수궤분위치료조화대조조.치료조매만복아탁벌타정20 mg,대조조급여안위제치료.비교량조치료전급치료제8、20주적간역지능상태량표、림상치태평정량표화일상생활자리량표평분.결과 치료8주시치료조、대조조각항량표평분여치료전비교차이무통계학의의(P>0.05);치료20주시치료조각항량표평분여치료전유현저개선(P<0.01),여대조조비교차이유통계학의의(P<0.05).결론 아탁벌타정대경、중도아이자해묵병합병고담고순자유일정뇌보호작용.
Objective To evaluate the neuroprotective effects of atovastatin for the treatment of mild to moderate Alzheimer's disease with high serum cholesterol. Methods Forty patients with mild to moderate Alzheimer's disease with high serum cholesterol were assigned into two groups randomily according to the orders of their visits, 20 patients in each group. The treated group received atovastatin 20 mg per night while the control group received the placebo. The total treatment course was 20 weeks. MMSE, Clinical dementia rating (CDR) and ADL were evaluated before and after 8, 20 weeks treatment. Results After 8 weeks treatment, MMSE, CDR and ADL changed a bit but with no significance compared with before treatment(P>0.05). After 20 weeks treatment MMSE, clinical dementia scale and ADL were improved significantly compared with before treatment (P<0.01), and compared with the control group(P<0.05).Conclusions The results mentioned above suggested that atovastatin had neuroprotective effects in the treatment of mild to moderate Alzheimer's disease with high serum cholesterol.
