CAJ | 학술논문

目的观察电针治疗对T10脊髓全横断尿潴留大鼠模型早期尿动力学指标的影响.方法将SD雌性大鼠31只按随机数字表法为假手术组(n=10)、模型组(n=11)和电针组(n=10),模型组和电针组建立脊髓全横断尿潴留大鼠模型,假手术组暴露T9、T10、T11的横突与棘突,不做任何损伤处理,于5min后直接缝合.电针组大鼠取“关元”、“三阴交”穴,采用连续波持续电刺激15min,每日治疗1次,连续治疗7d.假手术组和模型组进常规饲养.3组大鼠均于造模成功后第9天进行尿动力学检查.结果造模成功后第9天,电针组的残余尿量和膀胱容量分别为(2.79±0.59)ml和(4.60±0.73)ml,明显优于模型组的(5.18±0.61)ml和(6.43±0.85)ml,差异有统计学意义(P＜0.01)；而假手术组的残余尿量和膀胱容量最小,分别为(0.09±0.01)ml和(1.21±0.27)ml,与电针组和模型组比较,差异均有统计学意义(P＜0.01).电针组的排尿量和排尿率分别为(1.81±0.15)ml和(39.89±3.18)％,明显优于模型组的(1.26+0.29)ml和(19.56±2.56)％,差异有统计学意义(P＜0.01)；而假手术组的排尿率为(92.10±1.52)％,与电针组和模型组比较,差异均有统计学意义(P＜0.01).电针组的漏尿点膀胱压和膀胱顺应性分别为(11.22±1.66)cmH2O(1cmH2O=0.098kPa)和(0.35±0.19)ml/cmH2O,明显优于模型组的(14.00±1.39)cmH2O和(0.45±0.20)ml/cmH2O,差异有统计学意义(P＜0.01)；而假手术组的漏尿点膀胱压和膀胱顺应性最低,分别为(5.00±1.00)cmH2O和(0.24±0.14)ml/cmH2O,与电针组和模型组比较,差异均有统计学意义(P＜0.01).结论电针治疗可改善脊髓全横断大鼠早期的膀胱逼尿肌低反射状态和排尿功能.
목적 관찰전침치료대T10척수전횡단뇨저류대서모형조기뇨동역학지표적영향.방법 장SD자성대서31지안수궤수자표법위가수술조(n=10)、모형조(n=11)화전침조(n=10),모형조화전침조건립척수전횡단뇨저류대서모형,가수술조폭로T9、T10、T11적횡돌여극돌,불주임하손상처리,우5min후직접봉합.전침조대서취“관원”、“삼음교”혈,채용련속파지속전자격15min,매일치료1차,련속치료7d.가수술조화모형조진상규사양.3조대서균우조모성공후제9천진행뇨동역학검사.결과 조모성공후제9천,전침조적잔여뇨량화방광용량분별위(2.79±0.59)ml화(4.60±0.73)ml,명현우우모형조적(5.18±0.61)ml화(6.43±0.85)ml,차이유통계학의의(P＜0.01)；이가수술조적잔여뇨량화방광용량최소,분별위(0.09±0.01)ml화(1.21±0.27)ml,여전침조화모형조비교,차이균유통계학의의(P＜0.01).전침조적배뇨량화배뇨솔분별위(1.81±0.15)ml화(39.89±3.18)％,명현우우모형조적(1.26+0.29)ml화(19.56±2.56)％,차이유통계학의의(P＜0.01)；이가수술조적배뇨솔위(92.10±1.52)％,여전침조화모형조비교,차이균유통계학의의(P＜0.01).전침조적루뇨점방광압화방광순응성분별위(11.22±1.66)cmH2O(1cmH2O=0.098kPa)화(0.35±0.19)ml/cmH2O,명현우우모형조적(14.00±1.39)cmH2O화(0.45±0.20)ml/cmH2O,차이유통계학의의(P＜0.01)；이가수술조적루뇨점방광압화방광순응성최저,분별위(5.00±1.00)cmH2O화(0.24±0.14)ml/cmH2O,여전침조화모형조비교,차이균유통계학의의(P＜0.01).결론 전침치료가개선척수전횡단대서조기적방광핍뇨기저반사상태화배뇨공능.
Objective To observe the effect of electroacupuncture on urodynamic alteration in rats after complete T10 spinal cord transection.Methods Thirty-one female Sprague-Dawley rats were divided randomly into a sham operation group (n=10),a model group (n=11) and an electroacupuncture (EA) group (n=10).The spinal cords of the rats in the latter two groups were completely transected at the T10 level.Pressure was applied to the rats'lower abdomens every day while in the EA group electroacupuncture with continuous wave electricity was applied to the guanyuan (RN4) and sanyinjiao (SP6) acupoints for 15 min.The treatment was carried out daily for consecutive 7 days.Urodynamic examinations were carried out after the treatment course had finished.Results At the 9th day after the operation,average residual urine volume and bladder capacity in the EA group were both significantly lower than in the model group.Residual urine volume and bladder capacity were lowest in the sham operation group.Average voided volume and voiding rate in the EA group were significantly higher than in the model group.The average voiding rate was highest in the sham operation group.The average vesical pressure of the urine leak point and bladder compliance of the EA group rats were significantly lower than those of the model group The average vesical pressure of the urine leak point and bladder compliance of the sham operation group were lowest of all.All of these differences were statistically significant at the 1％ level of confidence.Conclusion EA can improve the lower bladder's detrusor reflex state and urinary tract function soon after complete T10 spinal cord transaction,at least in rats.