西安交通大学学报（医学版）
西安交通大學學報（醫學版）
서안교통대학학보（의학판）
JOURNAL OF XI'AN JIAOTONG UNIVERSITY(MEDICAL SCIENCES)
2009年
6期
762-765
,共4页
中医药%子宫腺肌症%基质金属蛋白酶-9%组织金属蛋白酶抑制剂-1%CA125
中醫藥%子宮腺肌癥%基質金屬蛋白酶-9%組織金屬蛋白酶抑製劑-1%CA125
중의약%자궁선기증%기질금속단백매-9%조직금속단백매억제제-1%CA125
Chinese Medicine%adenomyosis%matrix metalloproteinases-9%tissue inhibitors of metalloproteinases-1%CA125
目的 探讨中医药治疗子宫腺肌症的作用机制.方法 37例行全子宫切除术的子宫腺肌症患者术前分为中药治疗组(n=17)和对照组(n=20).子宫内膜作为在位内膜标本,腺肌瘤作为异位内膜标本.采用免疫组化法测定并比较在位和异位内膜中基质金属蛋白酶-9(MMP-9)和组织金属蛋白酶抑制剂-1(TIMP-1)的表达水平,并观察两组患者治疗前、后血清CA125的变化.结果 中药治疗组异位内膜组织中,MMP-9在腺上皮细胞内的表达显著低于对照组(P<0.05),TIMP-1的表达显著高于对照组(P<0.05),MMP-9/TIMP-1比值显著低于对照组(P<0.05).中药组治疗后血清CA125 明显降低,与治疗前及对照组比较差异均有统计学意义(P<0.05).结论 中药可能通过下调MMP-9/TIMP-1的比值及降低血清CA125水平来控制异位内膜组织的种植侵袭.
目的 探討中醫藥治療子宮腺肌癥的作用機製.方法 37例行全子宮切除術的子宮腺肌癥患者術前分為中藥治療組(n=17)和對照組(n=20).子宮內膜作為在位內膜標本,腺肌瘤作為異位內膜標本.採用免疫組化法測定併比較在位和異位內膜中基質金屬蛋白酶-9(MMP-9)和組織金屬蛋白酶抑製劑-1(TIMP-1)的錶達水平,併觀察兩組患者治療前、後血清CA125的變化.結果 中藥治療組異位內膜組織中,MMP-9在腺上皮細胞內的錶達顯著低于對照組(P<0.05),TIMP-1的錶達顯著高于對照組(P<0.05),MMP-9/TIMP-1比值顯著低于對照組(P<0.05).中藥組治療後血清CA125 明顯降低,與治療前及對照組比較差異均有統計學意義(P<0.05).結論 中藥可能通過下調MMP-9/TIMP-1的比值及降低血清CA125水平來控製異位內膜組織的種植侵襲.
목적 탐토중의약치료자궁선기증적작용궤제.방법 37례행전자궁절제술적자궁선기증환자술전분위중약치료조(n=17)화대조조(n=20).자궁내막작위재위내막표본,선기류작위이위내막표본.채용면역조화법측정병비교재위화이위내막중기질금속단백매-9(MMP-9)화조직금속단백매억제제-1(TIMP-1)적표체수평,병관찰량조환자치료전、후혈청CA125적변화.결과 중약치료조이위내막조직중,MMP-9재선상피세포내적표체현저저우대조조(P<0.05),TIMP-1적표체현저고우대조조(P<0.05),MMP-9/TIMP-1비치현저저우대조조(P<0.05).중약조치료후혈청CA125 명현강저,여치료전급대조조비교차이균유통계학의의(P<0.05).결론 중약가능통과하조MMP-9/TIMP-1적비치급강저혈청CA125수평래공제이위내막조직적충식침습.
Objective To study the mechanism of Chinese Medicine in treating adenomyosis. Methods Thirty-seven patients in the Chinese Medicine treated group (17 cases of adenomyosis) and the control group (20 cases of adenomyosis, non-drug treated) underwent hysterectomy. Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium. Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques. Meanwhile the levels of CA125 in serum were measured. Results The ectopic endometrium of the Chinese Medicine treated group expressed lower level of MMP-9, higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group (P<0.05). The levels of CA125 in serum were significantly decreased in Chinese Medicine group after treated as contrast with those in control group. Conclusion Chinese Medicine could reduce the level of CA125 and the ratio of MMP-9 and TIMP-1 to prevent the progression of adenomyosis.
