CAJ | 학술논문

细胞凋亡是机体维持自身稳定的一种基本生理机制,是有许多基因产物及细胞因子参与的一种有序的细胞自我消亡形式.细胞凋亡发生过程的启动和进行受到精确调控,具有独特而复杂的信号系统.各种凋亡信号通过信号传导通路传至细胞內,救活靶分子而产生细胞效应,引发细胞凋亡.一般认为,细胞凋亡存在3条主要通路:线粒体通路、内质网通路和死亡受体通路,各通路间互相联系,共同调节细胞凋亡.
세포조망시궤체유지자신은정적일충기본생리궤제,시유허다기인산물급세포인자삼여적일충유서적세포자아소망형식.세포조망발생과정적계동화진행수도정학조공,구유독특이복잡적신호계통.각충조망신호통과신호전도통로전지세포내,구활파분자이산생세포효응,인발세포조망.일반인위,세포조망존재3조주요통로:선립체통로、내질망통로화사망수체통로,각통로간호상련계,공동조절세포조망.
Apoptosis is a basic physiological mechanism of organism which maintain its stability,and one ordered form of cell death which involved an amount of genetic products and cellular factors. Apoptosis is a form of intrinsic cellular suicide program,which is a wide physiological process in muhicelular organisms and critical for the development,the cell senescence and the tissue homeostasis. The initial and progress of apoptosis is precisely regulated. This review summarized current knowledge of the signal transduction pathways of apoptosis. Broadly speaking,there are three pathways in apoptosis:death receptor pathway,mitochondrion pathway and endoplasmic reticulum pathway. These ways can cross-talk and regulate apoptosis coordinately.