CAJ | 학술논문

目的　探讨血管内皮生长因子（VEGF）在妊娠高血压综合征（妊高征）患者胎盘组织中的表达及对妊高征患者胎盘滋养细胞功能和绒毛毛细血管网形成的影响。方法　采用免疫组织化学SP法检测21例正常孕妇（对照组），60例妊高征患者（妊高征组，其中轻、中、重度妊高征患者各20例）胎盘组织VEGF的表达强度。结果　VEGF主要表达于胎盘绒毛滋养细胞；中度及重度妊高征患者胎盘绒毛滋养细胞VEGF表达强度均明显低于对照组及轻度妊高征患者(P＜0.05)，而轻度妊高征患者与对照组比较，差异无显著性(P＞0.05)，各组间蜕膜组织VEGF表达强度差异无显著性(P＞0.05)。　结论　VEGF在胎盘中主要由绒毛滋养细胞分泌，妊高征患者VEGF分泌减少，可能是引起局部胎盘绒毛及血管病变的原因之一。
목적　탐토혈관내피생장인자（VEGF）재임신고혈압종합정（임고정）환자태반조직중적표체급대임고정환자태반자양세포공능화융모모세혈관망형성적영향。방법　채용면역조직화학SP법검측21례정상잉부（대조조），60례임고정환자（임고정조，기중경、중、중도임고정환자각20례）태반조직VEGF적표체강도。결과　VEGF주요표체우태반융모자양세포；중도급중도임고정환자태반융모자양세포VEGF표체강도균명현저우대조조급경도임고정환자(P＜0.05)，이경도임고정환자여대조조비교，차이무현저성(P＞0.05)，각조간세막조직VEGF표체강도차이무현저성(P＞0.05)。　결론　VEGF재태반중주요유융모자양세포분비，임고정환자VEGF분비감소，가능시인기국부태반융모급혈관병변적원인지일。
Objective　To study the expression of vascular endothelial growth factor (VEGF) in placenta from normal pregnancy and pregnancy complicated with pregnancy induced hypertension (PIH) and the effect of VEGF on the etiology of PIH. Method　Use the immunohistochemistry to determine the location and intensity of VEGF staining in placenta from 21 cases of normal pregnancy and 62 cases of mild, moderate and severe group of pregnancies complicated with PIH. Result　Immunolocalization of VEGF in all cases was observed mainly in syncytiotrophoblast. Intensity of VEGF immnostaining in syncytiotrophoblast was significantly reduced in the moderate PIH group (P＜0.05) and the severe PIH group (P＜0.01) compared with both the mild PIH group and the normal group, while there was no qualitative differences between the mild PIH group and the normal group. Intensity of staining in decidual cells was also similar in all the groups. Conclusion　These results suggest that VEGF is secreted mainly by syncytiotrophoblast in human placenta and the reduced VEGF may be responsible, at least in part, for the impaired vascular development in PIH.