CAJ | 학술논문

目的探讨急性髓系白血病(AML)患者染色体核型异常发生率、分布以及美国西南肿瘤组与东部肿瘤协作组(SWOG/ECOG)染色体核型分组法在预后评价中的意义.方法常规培养83例AML患者的骨髓细胞,吉姆萨显带分析染色体核型.根据SWOG/ECOG核型分类方法对核型进行分组,采用Kaplan-Meier方法观察不同危险组的生存情况.结果 83例AML患者中56例细胞核型检出异常(67.47%).AML伴t(15;17)易位与伴t(8;21)易位在异常核型患者中所占比例为53.57%(30/56),其余核型分布较分散.随访的74例患者中,42例死亡.预后良好、中等、不良3组生存期比较差异具有统计学意义(P<0.001).预后良好组完全缓解率高于预后中等及不良组(P<0.05),预后中等组与不良组差异无统计学意义(P>0.05).结论细胞遗传学改变是影响白血病预后的主要因素之一,SWOG/ECOG核型分组能比较客观地反映AML的预后.
목적 탐토급성수계백혈병(AML)환자염색체핵형이상발생솔、분포이급미국서남종류조여동부종류협작조(SWOG/ECOG)염색체핵형분조법재예후평개중적의의.방법 상규배양83례AML환자적골수세포,길모살현대분석염색체핵형.근거SWOG/ECOG핵형분류방법대핵형진행분조,채용Kaplan-Meier방법관찰불동위험조적생존정황.결과 83례AML환자중56례세포핵형검출이상(67.47%).AML반t(15;17)역위여반t(8;21)역위재이상핵형환자중소점비례위53.57%(30/56),기여핵형분포교분산.수방적74례환자중,42례사망.예후량호、중등、불량3조생존기비교차이구유통계학의의(P<0.001).예후량호조완전완해솔고우예후중등급불량조(P<0.05),예후중등조여불량조차이무통계학의의(P>0.05).결론 세포유전학개변시영향백혈병예후적주요인소지일,SWOG/ECOG핵형분조능비교객관지반영AML적예후.
Objective To investigate the incidence and distribution of aberrational karyotype in acute myeloid leukemia (AML), and study the significance of the grouping by Southwest Oncology Group/Eastern Cooperative Oncology Group (SWOG/ECOG) in the prognosis of AML Methods The chromosome was prepared with brief culture of bone marrow, and the karyotype was analysed by G banding technique. All the patients were grouped according to the criterion of SWOG/ECOG, and the survival function of different groups was observed by the Kaplan-Meier method.Results 56 (67.47 %) out of 83 patients had clonal chromosome aberrations. Among those 56 patients, AML with translocation (15;17) and with translocation (8;21) presented in 30 patients(53.57 %), and the other kinds of aberrational karyotypes shared the left proportion. Among the 74 followed-up patients, 42 patients were dead. Among three groups with favorable, intermediate and adverse prognosis respectively, there is a significant difference (P <0.001). The complete remission rate of favorable group is higher than that of both intermediate and adverse (P <0.05). There is no difference between intermediate and adverse groups(P>0.05). Conclusion Cytogenetic aberration is one of the important factors affecting the effect on prognosis. The criterion of SWOG/ECOG can predict prognosis objectively.