CAJ | 학술논문

肿瘤抗原特异性T细胞受体(TCR)基因转导技术作为肿瘤过继性免疫治疗的新手段之一,细胞和动物实验都证明它有很好的抗肿瘤作用,但临床试验结果却不尽人意.影响临床疗效主要原因是肿瘤抗原特异性T细胞受体不能有效地表达于T淋巴细胞表面,因而探索提高抗原特异性TCR高效表达的方法可能是解决这种问题的必要途径.
종류항원특이성T세포수체(TCR)기인전도기술작위종류과계성면역치료적신수단지일,세포화동물실험도증명타유흔호적항종류작용,단림상시험결과각불진인의.영향림상료효주요원인시종류항원특이성T세포수체불능유효지표체우T림파세포표면,인이탐색제고항원특이성TCR고효표체적방법가능시해결저충문제적필요도경.
Redirecting T cell specificity by tumor antigen-specific T cell receptor(TCR) gene transfer, as one of new methods of tumor adoptive immunotherapy, has been proved that it has marked anti-tumor effect in vitro experiments and animal experiments. However, clinical trials were unsatisfactory due to ineffectively expression of tumor antigen-specific TCR in T lymphocytes. Thus, exploring approach to improve the expression of antigen-specific TCR may be an essential way to solve this problem.