CAJ | 학술논문

目的通过检测MMP-11、MMP-12在宫颈癌组织中的表达,探讨其与宫颈癌临床病理的关系,为诊治提供理论依据.方法采用免疫组化方法检测20例正常宫颈组织、36例宫颈上皮内瘤变组织(CIN)以及80例宫颈癌组织中MMP-11、MMP-12的表达情况,分析各组宫颈组织中的阳性表达与临床病理的关系.结果 (1)MMP-11及MMP-12在宫颈癌组织中的阳性表达率(82.50％,81.25％)高于宫颈非典型增生组织(69.44％,61.11％)和正常宫颈组织(5.00％,0,P＜0.05).(2)MMP-11及MMP-12的阳性表达与宫颈癌的组织学分级、临床分期、间质浸润深度、有无脉管入侵、有无淋巴结转移有关(P＜0.05).(3)宫颈癌组织中MMP-11与MMP-12的阳性表达呈正相关(rs=0.706,P＜0.05).结论 MMP-11及MMP-12在宫颈癌组织呈高表达,二者阳性表达在宫颈癌的浸润转移过程中起重要作用；联合检测MMP-11及MMP-12的表达可能对宫颈癌的早期诊断、判断肿瘤恶性程度及预后具有参考意义.
목적 통과검측MMP-11、MMP-12재궁경암조직중적표체,탐토기여궁경암림상병리적관계,위진치제공이론의거.방법 채용면역조화방법검측20례정상궁경조직、36례궁경상피내류변조직(CIN)이급80례궁경암조직중MMP-11、MMP-12적표체정황,분석각조궁경조직중적양성표체여림상병리적관계.결과 (1)MMP-11급MMP-12재궁경암조직중적양성표체솔(82.50％,81.25％)고우궁경비전형증생조직(69.44％,61.11％)화정상궁경조직(5.00％,0,P＜0.05).(2)MMP-11급MMP-12적양성표체여궁경암적조직학분급、림상분기、간질침윤심도、유무맥관입침、유무림파결전이유관(P＜0.05).(3)궁경암조직중MMP-11여MMP-12적양성표체정정상관(rs=0.706,P＜0.05).결론 MMP-11급MMP-12재궁경암조직정고표체,이자양성표체재궁경암적침윤전이과정중기중요작용；연합검측MMP-11급MMP-12적표체가능대궁경암적조기진단、판단종류악성정도급예후구유삼고의의.
Objective This study was aimed to determine the expression of matrix metalloproteinase-11 ( MMP-11 ) and MMP-12 in cervical cancer and the relationship between their expression with clinicopathological characteristics and the potential use as a prognostic and therapeutic agent.Methods Streptavidin-biotin-protein-linked peroxidase method(ie,SP) immunohistochemical method was used to detect the expression of MMP-11,MMP-12 in 20 cases of normal cervical tissue,36 cases of CIN tissue,g0 cases of cervical cancer.MMP-11 and 12 expression in cervical cancer and clinicopathological parameters of relevance were analyzed,and the relationship between MMP-1 1,-12 was studied in the development of cervical cancer for a preliminary study.Results The positive expression rate (82.50％,g1.25％ )of MMP-11 and-12 in cervical cancer was significantly higher than that of cervical dysplasia ( CIN ) specimens ( 69.44％,61.11％ ) and normal cervical tissues(5.00％,0),the difference was statistically significant ( P ＜0.05).(2)The expression of MMP-11 and-12 in cervical histological grade,clinical depth of stromal infiltration,with or without vascular invasion,with or without lymph stage,node metastasis was different.The difference was statistically significant ( P ＜0.05).(3)MMP-11 and-12 expression was significantly correlated.Conclusions The expression of MMP-11and-12 in cervical cancer tissues prompts that MMP-11 and-12 plays a central role in the course of invasion and metastasis of cervical carcinoma.MMP-11 and-12 joint detection may have a reference value in terms of the inchoate diagnosis of the cervical cancer,the evaluation and prognosis of tumor malignances degree.