CAJ | 학술논문

目的探讨复合微量营养素补充剂对健康成人体内营养素水平的影响。方法选择北京市152名推荐食谱问卷得分低于12分的健康成年人作为研究对象，采用随机数字表法分为安慰剂组和补充剂组，每组76名。两组分别服用安慰剂和复合微量营养素补充剂。8周后检测受试者血浆及尿液中营养素浓度的变化情况。并于研究第56天同时给两组受试者服用复合微量营养素补充剂，观察服药前和服药后2h血浆营养素水平变化。结果安慰剂组有3例失访，失访率为5.7％。服用复合微量营养素补充剂8周后，补充剂组的血浆α-生育酚[(18.23±0.82)比(14.55±0.73)μmol/L]、β-胡萝卜素[（4.28±0.29）比（2.38±0.24）μmol/L]、维生素C[(42.65±2.11)比(27.49±1.76)μmol/L]、B6[(323.51±15.88)比(69.43±10.47) nmol/L]和B12浓度[(1005.27±23.00)比(796.85±35.57) pmol/L]，尿维生素B1[(899.24±70.73)比(174.42±13.38) μg/g·Cr]和B2水平[(3227.68±330.04)比(259.10±33.33)μg/g·Cr]，及红细胞叶酸水平[(720.09±21.33)比(633.17±28.75) nmol/L]均明显高于安慰剂组（P均=0.0000），血浆γ-生育酚浓度明显低于安慰剂组[(2.18±0.13)比(2.87 ±0.26) μmol/L，P=0.0001]。服用复合微量营养素补充剂2h后，补充剂组的血浆维生素C水平明显高于安慰剂组[(54.53±2.43)比(23.02±1.77)mol/L，P=0.0000]。结论服用复合微量营养素补充剂可改变健康成人体内的营养素水平，但其意义有待进一步研究探讨。
목적 탐토복합미량영양소보충제대건강성인체내영양소수평적영향。방법 선택북경시152명추천식보문권득분저우12분적건강성년인작위연구대상，채용수궤수자표법분위안위제조화보충제조，매조76명。량조분별복용안위제화복합미량영양소보충제。8주후검측수시자혈장급뇨액중영양소농도적변화정황。병우연구제56천동시급량조수시자복용복합미량영양소보충제，관찰복약전화복약후2h혈장영양소수평변화。결과 안위제조유3례실방，실방솔위5.7％。복용복합미량영양소보충제8주후，보충제조적혈장α-생육분[(18.23±0.82)비(14.55±0.73)μmol/L]、β-호라복소[（4.28±0.29）비（2.38±0.24）μmol/L]、유생소C[(42.65±2.11)비(27.49±1.76)μmol/L]、B6[(323.51±15.88)비(69.43±10.47) nmol/L]화B12농도[(1005.27±23.00)비(796.85±35.57) pmol/L]，뇨유생소B1[(899.24±70.73)비(174.42±13.38) μg/g·Cr]화B2수평[(3227.68±330.04)비(259.10±33.33)μg/g·Cr]，급홍세포협산수평[(720.09±21.33)비(633.17±28.75) nmol/L]균명현고우안위제조（P균=0.0000），혈장γ-생육분농도명현저우안위제조[(2.18±0.13)비(2.87 ±0.26) μmol/L，P=0.0001]。복용복합미량영양소보충제2h후，보충제조적혈장유생소C수평명현고우안위제조[(54.53±2.43)비(23.02±1.77)mol/L，P=0.0000]。결론 복용복합미량영양소보충제가개변건강성인체내적영양소수평，단기의의유대진일보연구탐토。
Objective To determine the impact of multinutrient supplements on adult nutrient status in Beijing, China. Methods In this randomized, double-blind, and placebo controlled trial, 152 healthy adults with a Recommended Food Score lower than 12 were equally and randomly divided into multinutrient supplement group and placebo group. Plasma and urine nutrient levels including vitamin A, B1, B2, B6, B12, C, folate, α- and γ-tocopherol, and carotenoids were determined before and after 8-week intervention. Acute response on vitamin C,carotenoids and tocopherols status were also determined on day 56. Results Three cases (5.7％) were lost to follow-up in placebo group. Compared with the placebo group, α-tocopherol [(18.23 ±0.82) vs. (14.55 ±0.73) μmol/L], β-carotene [(4.28±0.29) vs. (2.38±0.24) μmol/L], vitamin C [(42.65 ±2. 11) vs.(27.49±1.76) μmol/L], B6 [(323.51 ±15.88) vs. (69.43±10.47) nmol/L] and B12 [(1005.27 ±23.00) vs. (796.85±35.57) pmol/L] levels in plasma, B1 [(899.24±70.73) vs. (174.42±13.38)μg/g · Cr]and B2 [(3227.68 ±330.04) vs. (259.10 ±33.33) μg/g · Cr] levels in urine, and folate level in red blood cells [(720.09 ±21.33) vs. (633.17 ±28.75) nmol/L] significantly increased after 8 weeks of intervention (all P=0.0000), while plasma γ-tocopherol level significantly decreased [(2.18 ±0.13) vs. (2.87 ±0.26) μmol/L,P=0.0001]. Significant acute response on vitamin C was also observed in the multinutrient supplement group [(54.53 ±2.43) vs. (23.02 ± 1.77) μmol/L, P =0.0000]. Conclusion This multinutrient supplement can effectively improve the nutrient status of healthy Chinese adults.