中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2009年
5期
301-304
,共4页
齐媛媛%彭晖%杨晓惠%孔令杰%高淑娜%江峰%付朝伟%虞秀珍%王宝涛%许爱娥%孟炜
齊媛媛%彭暉%楊曉惠%孔令傑%高淑娜%江峰%付朝偉%虞秀珍%王寶濤%許愛娥%孟煒
제원원%팽휘%양효혜%공령걸%고숙나%강봉%부조위%우수진%왕보도%허애아%맹위
红斑狼疮,系统性%受体,白细胞介素2%多态性,单核苷酸
紅斑狼瘡,繫統性%受體,白細胞介素2%多態性,單覈苷痠
홍반랑창,계통성%수체,백세포개소2%다태성,단핵감산
Lupus erythematosus,systemic%Receptors,interleukin-2%Polymorphism,single nucleotide
目的 探讨CD22基因T＞A位点(SNPrs2267574)与中国南方汉族人群系统性红斑狼疮(SLE)的遗传易感性及其表型间的相关性.方法 采用病例对照研究,收集215例病例和216例对照,应用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)技术进行基因分型,分析基因与疾病关联性以及表型相关性.结果 SLE患者组AT基因型的频率高于对照组(OR=1.68,95%CI:1.08～2.60,P=0.021);以T等位基因为参照,A等位基因的OR=1.58,95%CI:1.09～2.29,P=0.015;且A等位基因频率在抗SSA抗体阳性组高于抗SSA抗体阴性组(OR=3.69,95%CI:2.08～6.52,P＜0.01).结论 在中国南方汉族人群中,CD22基因T＞A位点与SLE具有相关性,抗SSA抗体的产生与A等位基因有关.
目的 探討CD22基因T＞A位點(SNPrs2267574)與中國南方漢族人群繫統性紅斑狼瘡(SLE)的遺傳易感性及其錶型間的相關性.方法 採用病例對照研究,收集215例病例和216例對照,應用聚閤酶鏈反應-限製性片段長度多態性分析(PCR-RFLP)技術進行基因分型,分析基因與疾病關聯性以及錶型相關性.結果 SLE患者組AT基因型的頻率高于對照組(OR=1.68,95%CI:1.08～2.60,P=0.021);以T等位基因為參照,A等位基因的OR=1.58,95%CI:1.09～2.29,P=0.015;且A等位基因頻率在抗SSA抗體暘性組高于抗SSA抗體陰性組(OR=3.69,95%CI:2.08～6.52,P＜0.01).結論 在中國南方漢族人群中,CD22基因T＞A位點與SLE具有相關性,抗SSA抗體的產生與A等位基因有關.
목적 탐토CD22기인T＞A위점(SNPrs2267574)여중국남방한족인군계통성홍반랑창(SLE)적유전역감성급기표형간적상관성.방법 채용병례대조연구,수집215례병례화216례대조,응용취합매련반응-한제성편단장도다태성분석(PCR-RFLP)기술진행기인분형,분석기인여질병관련성이급표형상관성.결과 SLE환자조AT기인형적빈솔고우대조조(OR=1.68,95%CI:1.08～2.60,P=0.021);이T등위기인위삼조,A등위기인적OR=1.58,95%CI:1.09～2.29,P=0.015;차A등위기인빈솔재항SSA항체양성조고우항SSA항체음성조(OR=3.69,95%CI:2.08～6.52,P＜0.01).결론 재중국남방한족인군중,CD22기인T＞A위점여SLE구유상관성,항SSA항체적산생여A등위기인유관.
Objective To explore the association of CD22 gene T＞A locus (SNPrs2267574) with the development of systemic lupus erythematosus (SLE) and SLE phenotypes in Southern Chinese Han people.Methods Two hundreds fifteen cases and 216 normal controls were enrolled with the aim of case-control design,and the genotype was determined by PCR-RFLP.We calculated X2 and ORs for association study.Results In CD22 gene T＞A locus,there was significant difference of genotypes distribution between cases and controls (X2=6.086,P＜0.05).The frequency of AT genotype was higher in cases than in controls (OR=1.68,95%CI:1.08～2.60,P=0.021 ),and A allele had a higher proportion in cases (OR=1.58,95%CI:1.09～2.29,P=0.015).Meanwhile,the frequency of A allele in patients with positive anti-SSA was higher than in patients with negative anti-SSA (OR=3.69,95%CI:2.08～6.52,P＜0.01 ).Conclusion In Southern Chinese Han population,CD22 gene T＞A locus is associated with the development of SLE and the A allele has positive association with anti-SSA.
