中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2011年
7期
544-546
,共3页
刘真真%卢振铎%张恒伟%杨辉%刘慧%李连方%李文亮%崔树德
劉真真%盧振鐸%張恆偉%楊輝%劉慧%李連方%李文亮%崔樹德
류진진%로진탁%장항위%양휘%류혜%리련방%리문량%최수덕
乳腺肿瘤%放射性核素显像%新辅助化疗%甲氧基异丁基异腈%预后
乳腺腫瘤%放射性覈素顯像%新輔助化療%甲氧基異丁基異腈%預後
유선종류%방사성핵소현상%신보조화료%갑양기이정기이정%예후
Breast neoplasms%Radionuclide imaging%Neoadjuvant chemotherapy%Methoxyisobutylisonitrile%Prognosis
目的 研究99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)亲肿瘤显像在可手术乳腺癌新辅助化疗疗效及预后预测中的价值.方法 对65例拟行新辅助化疗的可手术乳腺癌患者进行99Tcm-MIBI显像,采集10和180 min两时相的平面像,计算放射性清除率,分析清除率与化疗疗效和患者无病生存率的关系.结果 65例乳腺癌患者99Tcm-MIBI显像的放射性清除率为(17.4±6.8)%.新辅助化疗达完全缓解4例,部分缓解52例,疾病稳定8例,疾病进展1例,有效率为86.2%.新辅助化疗有效组和无效组的放射性清除率分别为(15.5±5.0)%和(29.2±3.2)%,差异有统计学意义(P＜0.001).高清除率组乳腺癌患者的无病生存率(53.1%)显著低于低清除率组(75.8%,P=0.046).结论 99Tcm-MIBI显像清除率可用于可手术乳腺癌新辅助化疗疗效的预测,并具有一定的预后价值.
目的 研究99Tcm-甲氧基異丁基異腈(99Tcm-MIBI)親腫瘤顯像在可手術乳腺癌新輔助化療療效及預後預測中的價值.方法 對65例擬行新輔助化療的可手術乳腺癌患者進行99Tcm-MIBI顯像,採集10和180 min兩時相的平麵像,計算放射性清除率,分析清除率與化療療效和患者無病生存率的關繫.結果 65例乳腺癌患者99Tcm-MIBI顯像的放射性清除率為(17.4±6.8)%.新輔助化療達完全緩解4例,部分緩解52例,疾病穩定8例,疾病進展1例,有效率為86.2%.新輔助化療有效組和無效組的放射性清除率分彆為(15.5±5.0)%和(29.2±3.2)%,差異有統計學意義(P＜0.001).高清除率組乳腺癌患者的無病生存率(53.1%)顯著低于低清除率組(75.8%,P=0.046).結論 99Tcm-MIBI顯像清除率可用于可手術乳腺癌新輔助化療療效的預測,併具有一定的預後價值.
목적 연구99Tcm-갑양기이정기이정(99Tcm-MIBI)친종류현상재가수술유선암신보조화료료효급예후예측중적개치.방법 대65례의행신보조화료적가수술유선암환자진행99Tcm-MIBI현상,채집10화180 min량시상적평면상,계산방사성청제솔,분석청제솔여화료료효화환자무병생존솔적관계.결과 65례유선암환자99Tcm-MIBI현상적방사성청제솔위(17.4±6.8)%.신보조화료체완전완해4례,부분완해52례,질병은정8례,질병진전1례,유효솔위86.2%.신보조화료유효조화무효조적방사성청제솔분별위(15.5±5.0)%화(29.2±3.2)%,차이유통계학의의(P＜0.001).고청제솔조유선암환자적무병생존솔(53.1%)현저저우저청제솔조(75.8%,P=0.046).결론 99Tcm-MIBI현상청제솔가용우가수술유선암신보조화료료효적예측,병구유일정적예후개치.
Objective To investigate the value of technetium-99m methoxyisobutylisonitrile (99Tcm-MIBI) imaging in predicting the efficacy of neoadjuvant chemotherapy (NCT) and prognosis in patients with operable breast cancer. Methods Sixty five patients with breast cancer underwent 99Tcm-MIBI scintimammography before NCT, and static planar images were taken at 10 min and 180 min after scintimammography. The clearance rate was calculated in each patient, correlation between the clearance rate and efficacy of NCT, and the disease free survival rate were analyzed. Results The mean clearance rate of 65 patients was (17.4±6.8)%. The efficacy of NCT was 86.2% (CR 4 cases, PR 52 cases, SD 8 cases, and PD 1 case), and the mean clearance rate of patients with good response or poor response of chemotherapy were (15.5±5.0)% and (29.2±3.2)%, respectively. There was a significant difference between the two groups. The average disease free survival rate in the group with low clearance rate was (75.8%,P=0.046), significantly higher than that in the group with high clearance rate (53. 1%). Conclusion Scintimammography of 99Tcm-MIBI may be used to evaluate the efficacy and prognosis of NCT for patients with operable breast cancer.
