CAJ | 학술논문

目的探讨川崎病患儿血脂变化与冠状动脉病变的关系.方法采用氧化酶法和GPO-POD酶法分别测定46例川崎病患儿及30例健康儿童的血三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白(HDL-C).结果川崎病患儿急性期治疗前血TG、TC及LDL-C增高,与正常对照组间差异有统计学意义(P<0.05),血HDL-C降低,与正常对照组间差异有统计学意义(P<0.05).治疗后未并发冠脉病变组TG、TC及LDL - C均较治疗前降低,与治疗前相比差异有统计学意义(P<0.05),HDL-C较治疗前升高,与治疗前相比差异有统计学意义(P<0.01),与正常对照组相比差异无统计学意义(P>0.05);而并发冠状动脉病变组血脂各指标与治疗前比较差异无统计学意义(P>0.05).结论血脂的动态测定可预测川崎病患儿并发冠状动脉病变的发生,有助于早期诊断.
목적 탐토천기병환인혈지변화여관상동맥병변적관계.방법 채용양화매법화GPO-POD매법분별측정46례천기병환인급30례건강인동적혈삼선감유(TG)、담고순(TC)、저밀도지단백담고순(LDL-C)화고밀도지단백(HDL-C).결과 천기병환인급성기치료전혈TG、TC급LDL-C증고,여정상대조조간차이유통계학의의(P<0.05),혈HDL-C강저,여정상대조조간차이유통계학의의(P<0.05).치료후미병발관맥병변조TG、TC급LDL - C균교치료전강저,여치료전상비차이유통계학의의(P<0.05),HDL-C교치료전승고,여치료전상비차이유통계학의의(P<0.01),여정상대조조상비차이무통계학의의(P>0.05);이병발관상동맥병변조혈지각지표여치료전비교차이무통계학의의(P>0.05).결론 혈지적동태측정가예측천기병환인병발관상동맥병변적발생,유조우조기진단.
Objective To study the relationship between the changes of serum lipid and the pathological changes of coronary artery in children with Kawasaki disease(KD).Methods The levels of serum TG,TC,LDL-C and HDL-C were determined by methods of oxidase and GPO-POD in 46 KD and 30 healthy children.Results The levels of TG,TC,LDL-C increased and HDL-C decreased in KD children in acute phase before treatment,significantly different from those in control group (P＜0.05).TG,TC,LDL-C decreased (P＜0.05),and HDL-C increased(P＜0.01) in group without coronary artery lesion(CAL) after treatment as compared with pretreatment,not significantly different from normal control group(P＞0.05).No significant difference was noted in various indicators of blood lipid between pre- and post-treatments in CAL group(P＞0.05).Conclusion Dynamic determination of blood lipid,which can predict the occurrence of KD with CAL,is helpful in its early diagnoses.