北京医学
北京醫學
북경의학
BEIJING MEDICAL JOURNAL
2010年
3期
210-213
,共4页
李丽%于海滨%闾军%韩大康
李麗%于海濱%閭軍%韓大康
리려%우해빈%려군%한대강
HBeAg阳性%慢性乙型肝炎%肝活检%危险因素
HBeAg暘性%慢性乙型肝炎%肝活檢%危險因素
HBeAg양성%만성을형간염%간활검%위험인소
HBeAg-positive%Chronic hepatitis B%Liver biopsy%Risk factors
目的 了解HBeAg阳性慢性乙型肝炎患者年龄、性别、HBV DNA载量、乙肝家族史等因素不同水平之间炎症纤维化程度的构成差异. 方法 回顾性分析了我院2年来行肝活检的179例HBeAg阳性慢性乙型肝炎患者资料,对上述因素进行分层分析. 结果 多数患者30岁以前即开始进入免疫清除期,中重度纤维化多见于40岁以上;男女发病人数比值约为3.5∶1,男性G≥2的患者比例明显高于女性,但男女之间纤维化构成比无差别;HBVDNA处于10~4～10~6 copies/ml水平时,中重度炎症(G≥2,76.5%)最为显著,HBVDNA<10~4 copies/ml的患者中重度纤维化比例(S≥2,62.5%)最高.有家族史的患者约占40%,较无家族史者G≥2比例更高(71.2%vs.61%),但纤维化程度方面无差别. 结论 HBeAg阳性患者年龄、性别、HBVDNA水平、乙肝家族史等因素不同水平间炎症纤维化程度存在构成比差异,对<40岁、女性、HBVDNA<104copies/ml及无乙肝家族史的患者,也要给予足够重视.
目的 瞭解HBeAg暘性慢性乙型肝炎患者年齡、性彆、HBV DNA載量、乙肝傢族史等因素不同水平之間炎癥纖維化程度的構成差異. 方法 迴顧性分析瞭我院2年來行肝活檢的179例HBeAg暘性慢性乙型肝炎患者資料,對上述因素進行分層分析. 結果 多數患者30歲以前即開始進入免疫清除期,中重度纖維化多見于40歲以上;男女髮病人數比值約為3.5∶1,男性G≥2的患者比例明顯高于女性,但男女之間纖維化構成比無差彆;HBVDNA處于10~4～10~6 copies/ml水平時,中重度炎癥(G≥2,76.5%)最為顯著,HBVDNA<10~4 copies/ml的患者中重度纖維化比例(S≥2,62.5%)最高.有傢族史的患者約佔40%,較無傢族史者G≥2比例更高(71.2%vs.61%),但纖維化程度方麵無差彆. 結論 HBeAg暘性患者年齡、性彆、HBVDNA水平、乙肝傢族史等因素不同水平間炎癥纖維化程度存在構成比差異,對<40歲、女性、HBVDNA<104copies/ml及無乙肝傢族史的患者,也要給予足夠重視.
목적 료해HBeAg양성만성을형간염환자년령、성별、HBV DNA재량、을간가족사등인소불동수평지간염증섬유화정도적구성차이. 방법 회고성분석료아원2년래행간활검적179례HBeAg양성만성을형간염환자자료,대상술인소진행분층분석. 결과 다수환자30세이전즉개시진입면역청제기,중중도섬유화다견우40세이상;남녀발병인수비치약위3.5∶1,남성G≥2적환자비례명현고우녀성,단남녀지간섬유화구성비무차별;HBVDNA처우10~4～10~6 copies/ml수평시,중중도염증(G≥2,76.5%)최위현저,HBVDNA<10~4 copies/ml적환자중중도섬유화비례(S≥2,62.5%)최고.유가족사적환자약점40%,교무가족사자G≥2비례경고(71.2%vs.61%),단섬유화정도방면무차별. 결론 HBeAg양성환자년령、성별、HBVDNA수평、을간가족사등인소불동수평간염증섬유화정도존재구성비차이,대<40세、녀성、HBVDNA<104copies/ml급무을간가족사적환자,야요급여족구중시.
Objective To understand the composition differences of inflammation and fibrosis among the different parameters such as age,sex,HBV DNA load,hepatitis B family history in patients with HBeAg-positive chronic hepatitis B. Methods 179 patients with HBeAg-positive chronic hepatitis B were all from our hospital and given liver biopsy within two years.Data were retrospectively analyzed based on the stratified levels of above parameters. Results Most of patients initiating the immune clearance phase were before 30 years old.Patients with fibrosis (moderate and severe) were prevalent after 40 years old.The ratio of male to female was approximately 3.5:1.Male patients with G ≥ 2 was significantly higher than that of female,but there was no difference in composition ratio of fibrosis between men and women.Patients with HBV DNA load at 10~4～10~6 copies/ml were mostly characterized by moderate to severe inflammation (G≥2,76.5%) and 62.5% patients with HBV DNA<10~4 copies/ml were with mederate to severe fibrosis (S≥2).About 40% of patients had family hepatitis B history.Patients with family history had higher percentage of G ≥ 2 compared to those without family history (71.2% vs 61%),but no difference were observed in fibrosis level between these two groups. Conclusions Composition differences of inflammation and fibrosis were observed in different parameters such as age,sex,HBV DNA load,hepatitis B family history.Our data showed that patients with even before 40-year-old,female,HBVDNA <10~4 copies/ml or without family history should also be paid attention in clinical practice.
