中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
11期
1073-1074
,共2页
张广政%刘键%王艳丽%乐晓萍%张钦宪
張廣政%劉鍵%王豔麗%樂曉萍%張欽憲
장엄정%류건%왕염려%악효평%장흠헌
胃癌%ZAC%生长抑素%免疫组织化学
胃癌%ZAC%生長抑素%免疫組織化學
위암%ZAC%생장억소%면역조직화학
Gastric cancer%ZAC%Somatostatin%Immunohistochemistry
目的 研究胃癌组织中ZAC和生长抑素表达的相关性,探讨胃癌组织中ZAC与生长抑素的表达与胃癌临床病理学特性的关系.方法 应用免疫组织化学技术检测30例胃癌患者手术切除标本及其相应癌旁组织和正常胃黏膜组织中ZAC和生长抑素的表达.结果 胃癌、癌旁及正常胃黏膜组织中ZAC的阳性表达率分别为33.3%(10/30)、73.3%(22/30)和66.7%(20/30);生长抑素的阳性表达率分别为36.7%(11/30)、53.3%(16/30)和73.3%(22/30).胃癌组织中ZAC和生长抑素的表达阳性率均明显低于正常胃黏膜组织(均P<0.05).胃癌组织中ZAC与生长抑素的表达呈明显正相关(r=0.636,P<0.05).ZAC与生长抑素的共表达与胃癌的分化程度及浸润深度有明显关系(P<0.05),而与淋巴结转移无明显关系(P>0.05).结论 胃癌组织中ZAC与生长抑素的表达具有明显相关性,生长抑素可能与ZAC协同参与胃癌的发生和发展.
目的 研究胃癌組織中ZAC和生長抑素錶達的相關性,探討胃癌組織中ZAC與生長抑素的錶達與胃癌臨床病理學特性的關繫.方法 應用免疫組織化學技術檢測30例胃癌患者手術切除標本及其相應癌徬組織和正常胃黏膜組織中ZAC和生長抑素的錶達.結果 胃癌、癌徬及正常胃黏膜組織中ZAC的暘性錶達率分彆為33.3%(10/30)、73.3%(22/30)和66.7%(20/30);生長抑素的暘性錶達率分彆為36.7%(11/30)、53.3%(16/30)和73.3%(22/30).胃癌組織中ZAC和生長抑素的錶達暘性率均明顯低于正常胃黏膜組織(均P<0.05).胃癌組織中ZAC與生長抑素的錶達呈明顯正相關(r=0.636,P<0.05).ZAC與生長抑素的共錶達與胃癌的分化程度及浸潤深度有明顯關繫(P<0.05),而與淋巴結轉移無明顯關繫(P>0.05).結論 胃癌組織中ZAC與生長抑素的錶達具有明顯相關性,生長抑素可能與ZAC協同參與胃癌的髮生和髮展.
목적 연구위암조직중ZAC화생장억소표체적상관성,탐토위암조직중ZAC여생장억소적표체여위암림상병이학특성적관계.방법 응용면역조직화학기술검측30례위암환자수술절제표본급기상응암방조직화정상위점막조직중ZAC화생장억소적표체.결과 위암、암방급정상위점막조직중ZAC적양성표체솔분별위33.3%(10/30)、73.3%(22/30)화66.7%(20/30);생장억소적양성표체솔분별위36.7%(11/30)、53.3%(16/30)화73.3%(22/30).위암조직중ZAC화생장억소적표체양성솔균명현저우정상위점막조직(균P<0.05).위암조직중ZAC여생장억소적표체정명현정상관(r=0.636,P<0.05).ZAC여생장억소적공표체여위암적분화정도급침윤심도유명현관계(P<0.05),이여림파결전이무명현관계(P>0.05).결론 위암조직중ZAC여생장억소적표체구유명현상관성,생장억소가능여ZAC협동삼여위암적발생화발전.
Objective To study the correlation of ZAC and somatostatin (SST) expression in gastric cancer tissues, and explore the relationship between expression of ZAC and SST with clinicopethological factors of gastric cancer,and the correlation between ZAC and SST. Methods Immunohistochemistry was performed to detect the ex-pression of ZAC and SST in gastric cancer tissues (n =30 cases) ,gastric tissues adjacent to cancer and normal gas-tric mucosa tissues. Results The positive rate of ZAC in gastric cancer tissues, gastric tissues adjacent to cancer and normal gastric mucosa tissues was 33.3 % (10/30) ,73.3 % (22/30) and 66.7 % (20/30) respectively; that of SST was 36.7% (11/30) ,53.3% (16/30) and 73.3% (22/30) respectively. The positive rates of beth ZAC and SST in gastric cancer tissues were significantly lower than those in normal gastric mucosa tissues (P < 0.05). ZAC expres-sion was positively correlated with SST expression in gastric cancer tissues (r = 0. 636 ,P < 0.05). Co-expression of ZAC and SST was obviously related to differentiation type and infiltration degree (P <0.05). However,no relation was found between co-expression of ZAC and SST and lymph node metastasis (P > 0.05). Conclusion ZAC is sig-nificantly correlated with SST in gastric cancer tissues. SST and ZAC may be involved in the development and pro-gression of gastric cancer.
