CAJ | 학술논문

目的分析X刀分次立体定向放疗(FSRT)联合全脑照射(WBRT)治疗脑转移瘤疗效.方法回顾性分析51例脑转移瘤FSRT+WBRT和35例脑转移瘤单纯WBRT的结果,比较分析两者有效率、生存率的差异.结果 FSRT+WBRT、WBRT组完全缓解率分别为49%、26%(P<0.05),中位生存期分别为(11.0±1.5)、(6.5±0.5)个月(P<0.05),18个月生存率分别为24%、9%(P<0.05).两组有效率(8%、71%,P0.05)和6、12个月生存率(63%、41%,51%、23%,P0.05)相似.结论 X刀FSRT联合WBRT治疗脑转移瘤损伤小、安全、延长生存期,疗效优于单纯全颅放疗.
목적 분석X도분차입체정향방료(FSRT)연합전뇌조사(WBRT)치료뇌전이류료효.방법 회고성분석51례뇌전이류FSRT+WBRT화35례뇌전이류단순WBRT적결과,비교분석량자유효솔、생존솔적차이.결과 FSRT+WBRT、WBRT조완전완해솔분별위49%、26%(P<0.05),중위생존기분별위(11.0±1.5)、(6.5±0.5)개월(P<0.05),18개월생존솔분별위24%、9%(P<0.05).량조유효솔(8%、71%,P0.05)화6、12개월생존솔(63%、41%,51%、23%,P0.05)상사.결론 X도FSRT연합WBRT치료뇌전이류손상소、안전、연장생존기,료효우우단순전로방료.
Objective To evaluate efficiency of brain metastases tumor using X-knife under farctionational stereotactie radiotherapy (FSRT) combine with whole brain radiotherapy (WBRT). Methods Retrospective comparing 51 patients treated by FSRT plus WBRT (FSRT + WBRT group) with 35 patients treated by WBRT alone (WBRT group) on the effecting rate and survival rate. Results The completeness response rate was 49 % and 26 % (P < 0.05) in FSRT + WBRT and WBRT groups, respectively. The effecting rate was 80 % and 71 % (P 0.05) in FSRT + WBRT and WBRT groups, respectively. The middle survival time was (11.0 ± 1.5) months and (6.5 ± 0.5) months (P < 0.05) in FSRT + WBRT and WBRT groups, respeetivley. The 0.5-, 1.0- and 1.5-years survival rate was 63 % and 41 % (P 0.05), 51 % and 23 % (P 0.05) and 24 % and 9 % (P < 0.05) in FSRT + WBRT and WBRT groups, respectively. Conclusions The method with FSRT plus WBRT in the treatment of brain metastases tumor is safe and relieved focal symptom of patients quickly with lesser injury on normal tissue and the survival time be prolonged, it has better therapeutic effects than WBRT alone for treating brain metastases tumor.