中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2010年
9期
585-587
,共3页
胃肠道间质瘤%ANO1蛋白,人类%诊断
胃腸道間質瘤%ANO1蛋白,人類%診斷
위장도간질류%ANO1단백,인류%진단
Gastrointestinal stromal tumors%ANO1 protein,human%Diagnosis
目的 分析DOG1蛋白与胃肠道间质瘤(GIST)的相关性.方法 收集2005年1月至2010年6月77例GIST患者,应用免疫组化法检测GIST中DOG1蛋白的表达,并结合原有免疫组化指标CD117、CD34的检测结果进行对照分析.结果 77例GIST患者中,DOG1蛋白和CD117的阳性表达率分别为96.1%(74/77)和90.9%(70/77),两组间差异无统计学意义(P＞0.05).不同性别、年龄组、病变部位及危险度间DOG1蛋白阳性表达率差异亦无统计学意义(P值均＞0.05).7例CD117阴性表达的GIST患者中6例DOG1蛋白阳性表达.3例DOG1蛋白阴性表达的GIST中2例CD117阳性表达.结论 DOG1蛋白作为一种新的GIST标志物,具有与CD117同样的高敏感性,与CD117联用于GIST诊断互补性较好,尤其对CD117阴性的GlST诊断价值优势较大,但不能作为划分GIST危险度的指标.
目的 分析DOG1蛋白與胃腸道間質瘤(GIST)的相關性.方法 收集2005年1月至2010年6月77例GIST患者,應用免疫組化法檢測GIST中DOG1蛋白的錶達,併結閤原有免疫組化指標CD117、CD34的檢測結果進行對照分析.結果 77例GIST患者中,DOG1蛋白和CD117的暘性錶達率分彆為96.1%(74/77)和90.9%(70/77),兩組間差異無統計學意義(P＞0.05).不同性彆、年齡組、病變部位及危險度間DOG1蛋白暘性錶達率差異亦無統計學意義(P值均＞0.05).7例CD117陰性錶達的GIST患者中6例DOG1蛋白暘性錶達.3例DOG1蛋白陰性錶達的GIST中2例CD117暘性錶達.結論 DOG1蛋白作為一種新的GIST標誌物,具有與CD117同樣的高敏感性,與CD117聯用于GIST診斷互補性較好,尤其對CD117陰性的GlST診斷價值優勢較大,但不能作為劃分GIST危險度的指標.
목적 분석DOG1단백여위장도간질류(GIST)적상관성.방법 수집2005년1월지2010년6월77례GIST환자,응용면역조화법검측GIST중DOG1단백적표체,병결합원유면역조화지표CD117、CD34적검측결과진행대조분석.결과 77례GIST환자중,DOG1단백화CD117적양성표체솔분별위96.1%(74/77)화90.9%(70/77),량조간차이무통계학의의(P＞0.05).불동성별、년령조、병변부위급위험도간DOG1단백양성표체솔차이역무통계학의의(P치균＞0.05).7례CD117음성표체적GIST환자중6례DOG1단백양성표체.3례DOG1단백음성표체적GIST중2례CD117양성표체.결론 DOG1단백작위일충신적GIST표지물,구유여CD117동양적고민감성,여CD117련용우GIST진단호보성교호,우기대CD117음성적GlST진단개치우세교대,단불능작위화분GIST위험도적지표.
Objective To analyze the association of DOG1 protein with gastrointestinal stromal tumors(GIST). Methods Seventy-seven patients diagnosed with GIST between January 2005 and June 2010 were enrolled. The DOG1 expression in GIST was determined using immunohistochemistry.The result was compared with that of CD117 and CD34. Results Of 77 GIST patients, the DOG1 was expressed in 74 (96.10%) patients and CD117 in 70 (90. 9%) patients, with no significant difference between DOG1 and CD117 (P＞0.05). DOG1 expression was not related to the risk stratification of the tumor, site, age and gender (P＞0. 05). Of 7 GIST patients with negative CD117,6 patients were positive for DOG1 expression. Whereas 2 of 3 DOG1 negative patients were positive for CD117 expression. Conclusions DOG1, as a novel marker for GIST,has high sensitivity as CD117. It is a good complementarity in diagnosis of GIST when combine DOG1 with CD117, especially in diagnosis of CD117 negative patients. However, the DOG1 can not be used as an index in eveluating the risk stratification of the GIST.
