CAJ | 학술논문

目的随访观察老年轻度认知功能损害(MCI)患者认知水平的变化特点.方法以2008年某军队干休所MCI患者47例及正常对照21名为研究对象,随访一年,在初次确诊以及一年后分别进行蒙特利尔认知评估表(MoCA)中文版、简易精神状态检查表(MMSE)和画钟测验(CDT)等神经心理评估.结果随访一年后,MCI组MMSE量表总分、MoCA量表总分及视空间、延迟回忆分项得分和CDT得分与基线得分比较均有不同程度下降,其中MoCA量表总分及延迟回忆分项得分随访后与基线间差异有统计学意义(P=0.041,P=0.003);正常对照组MoCA量表总分、定向力、视空间、延迟回忆分项得分以及CDT得分也有不同程度下降,但差异无统计学意义.结论延迟回忆受损是老年MCI患者认知水平变化的早期特征性表现.
목적 수방관찰노년경도인지공능손해(MCI)환자인지수평적변화특점.방법 이2008년모군대간휴소MCI환자47례급정상대조21명위연구대상,수방일년,재초차학진이급일년후분별진행몽특리이인지평고표(MoCA)중문판、간역정신상태검사표(MMSE)화화종측험(CDT)등신경심리평고.결과 수방일년후,MCI조MMSE량표총분、MoCA량표총분급시공간、연지회억분항득분화CDT득분여기선득분비교균유불동정도하강,기중MoCA량표총분급연지회억분항득분수방후여기선간차이유통계학의의(P=0.041,P=0.003);정상대조조MoCA량표총분、정향력、시공간、연지회억분항득분이급CDT득분야유불동정도하강,단차이무통계학의의.결론 연지회억수손시노년MCI환자인지수평변화적조기특정성표현.
Objective To observe and assess the cognitive changes of mild cognitive impairment (MCI) in the elderly. Methods A cohort study design was conducted among 47 patients with MCI and 21 control selected from the same convalescent camp, Montreal cognitive assessment ( MoCA ), mini mental state examination (MMSE)and clock drawing test (CDT) were performed to all subjects at the onset of study and 12 months later. Results The score of MMSE, CDT, MoCA and its subitems including visuospatial skill and delayed recall of MCI group were lower than the baseline afer12 months, with significantly decline in the score of MoCA( P= 0. 041 )and delay recall (P = 0. 003 ). There was no obvious difference in the score of control between the baseline and that afer12 months. Conclusion The decline of delayed recall occurred early and significantly, which may be a predictor in the conversion of mild cognitive impairment to dementia.