CAJ | 학술논문

目的探讨毒性弥漫性甲状腺肿(Graves病)患者胰岛素(Ins)水平与低钾周期性麻痹的关系. 方法选择1998～2001年在我院门诊和住院的232例Graves病患者,均予检测血钾、糖化血红蛋白和口服葡萄糖耐量试验(OGTT)、血浆Ins、C肽释放试验,并与43名健康成人比较. 结果 (1)甲状腺功能亢进症(甲亢)伴低钾周期性麻痹的患者全部为男性.(2)甲亢患者有葡萄糖耐量受损和高胰岛素血症,表现为OGTT中2h血糖不能达到正常水平,有低钾周期性麻痹患者最为明显,为(10±3) mmol/L.甲亢伴低钾周期性麻痹患者胰岛素和C肽释放分别为(中位数):18.05、67.80、95.50、119.00、75.00 mU/L和2.97、6.00、7.60、11.80、6.90 μg/L,明显高于健康成人和无低钾周期性麻痹的甲亢患者,差异有显著意义. 结论甲亢伴低钾周期性麻痹患者存在高胰岛素血症和葡萄糖耐量异常,血清钾下降与血浆胰岛素增高、血钾向细胞内转移有关.预防和治疗高胰岛素血症也是预防和治疗甲亢伴低钾周期性麻痹的又一措施.
목적 탐토독성미만성갑상선종(Graves병)환자이도소(Ins)수평여저갑주기성마비적관계. 방법선택1998～2001년재아원문진화주원적232례Graves병환자,균여검측혈갑、당화혈홍단백화구복포도당내량시험(OGTT)、혈장Ins、C태석방시험,병여43명건강성인비교. 결과 (1)갑상선공능항진증(갑항)반저갑주기성마비적환자전부위남성.(2)갑항환자유포도당내량수손화고이도소혈증,표현위OGTT중2h혈당불능체도정상수평,유저갑주기성마비환자최위명현,위(10±3) mmol/L.갑항반저갑주기성마비환자이도소화C태석방분별위(중위수):18.05、67.80、95.50、119.00、75.00 mU/L화2.97、6.00、7.60、11.80、6.90 μg/L,명현고우건강성인화무저갑주기성마비적갑항환자,차이유현저의의. 결론갑항반저갑주기성마비환자존재고이도소혈증화포도당내량이상,혈청갑하강여혈장이도소증고、혈갑향세포내전이유관.예방화치료고이도소혈증야시예방화치료갑항반저갑주기성마비적우일조시.
Objective To investigate relationship between serum insulin level and hypokalemic myoparalgsis in Graves’ hyperthyroidism Methods We investigated 232 in patients with hyperthyroidism from 1998 to 2001 HbA 1c, OGTT, and serum insulin and C peptide levels were analyzed Results At 0,30,60,120,180 muinutes after OGTT blood glucose levels were 4 59,7 87,8 00,5 93,4 50 (mmol/L) respectively in normal control, but were 5 07,8 89,10 50,10 10,5 83 (mmol/L) respectiwely in hypokalemic periodic paralysis in hyperthyroidism At 0,30,60,120,180 minutes after OGTT, insulin and c peptide levels were10 10,40 00,55 40,53 30,31 40 (mU/L) and 1 88,4 00,6 18,6 41,5 14(μg/L) respectively in normal contol but were 18 05,67 80,95 50,119 00,75 00(mU/L) and 2 97,6 00,7 60,11 80,6 90 (μg/L) respectively in hypokalemic periodic paralysis Conclusion The hyperthyroidism patients have hyperinsulinemia and impaired glucose tolerance, which may be associated with hypokalemic paralysis.