α-萘甲醇衍生物的选择性氧化及手性联萘二酸的合成
α-내갑순연생물적선택성양화급수성련내이산적합성
Selective Oxidation of α-Naphthyl Methanol Derivatives and Synthesis of Optically Pure 1,1′-Binaphthyl-2,2′-dicarboxylic Acid
  • 万方数据
    合成化学 합성화학
    CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
    2010年 1期 6-9 ,共4页

    张万轩%曹锰%叶康%黄巍

    장만헌%조맹%협강%황외

    α-萘甲醇%光学纯联萘二酸%选择性氧化%合成 α-萘甲醇%光學純聯萘二痠%選擇性氧化%閤成
    α-내갑순%광학순련내이산%선택성양화%합성
    naphthyl methanol%optically pure 1,1′-binaphthyl-2,2′-dicarboxylic acid%selective oxidation%synthesis
    α-萘甲醇衍生物与负载型氧化剂A(KMnO_4/CuSO_4·5H_2O)反应,得到相应的醛(酮),产率68%～98%.光学纯的(S)-联萘二醇经A氧化制得光学纯的(S)-联萘二醛;醛经MnO_2再次氧化合成了(S)-联萘二酸二甲酯;酯水解得到光学纯的(S)-联萘二酸.
    α-내갑순연생물여부재형양화제A(KMnO_4/CuSO_4·5H_2O)반응,득도상응적철(동),산솔68%～98%.광학순적(S)-련내이순경A양화제득광학순적(S)-련내이철;철경MnO_2재차양화합성료(S)-련내이산이갑지;지수해득도광학순적(S)-련내이산.
    α-Naphthyl methanol derivatives were selectively oxidized with potassium permanganate adsorbed on a solid support of copper sulfate pentahydrate KMnO_4/CuSO_4·5H_2O(A) to obtain aldehydes or ketones in good yields(68%~98%).(S)-1,1′-binaphthyl-2,2′-dicarbaldehyde was prepared by selective oxidation of (S)-2,2′-bis(hydroxymethyl)- 1,1′-binaphthyl using A as oxidant.The aldehyde was oxidized by MnO_2 giving (S)-dimethyl-1,1′-binaphthyl-2,2′-dicarboxylate,which was converted into (S)-1,1′-binaphthyl-2,2′-dicarboxylic acid by hydrolysis.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문