CAJ | 학술논문

目的探讨肢端肥大症患者病情活动期与缓解后身体组分的变化与生长激素(GH)、类胰岛素生长因子-1(IGF-1)水平的相关性.方法治疗前后患者做生长激素葡萄糖抑制试验(OGTT),测定GH谷值、窄腹IGF-1水平;使用体脂分析仪测定身高、体质量、脂肪了丁分含量(fat%)、去脂肪量(FFM)和身体总水量(TBW).结果活动期男性患者体重指数(BMI)和FFM显著高于正常对照,脂肪百分含量则显著低于后者;缓解后,患者GH谷值和IGF-1水平明显下降,BMI仍显著高于正常男性,而脂肪百分含量和FFM分别呈现增加和减少的趋势,与GH谷值和IGF1水平的降低显著相关.活动期女性患者与正常女性比较,BMI、FFM显著高于后者,而两者脂肪百分含量无显著差异;缓解后,患者FFM逐渐减少,与GH谷值显著相关,脂肪百分含量无明显变化.结论肢端肥大症患者身体组分与正常人相比差异显著.缓解后身体组分发生变化,与GH谷值、IGF-1水平密切相关.
목적 탐토지단비대증환자병정활동기여완해후신체조분적변화여생장격소(GH)、류이도소생장인자-1(IGF-1)수평적상관성.방법 치료전후환자주생장격소포도당억제시험(OGTT),측정GH곡치、착복IGF-1수평;사용체지분석의측정신고、체질량、지방료정분함량(fat%)、거지방량(FFM)화신체총수량(TBW).결과 활동기남성환자체중지수(BMI)화FFM현저고우정상대조,지방백분함량칙현저저우후자;완해후,환자GH곡치화IGF-1수평명현하강,BMI잉현저고우정상남성,이지방백분함량화FFM분별정현증가화감소적추세,여GH곡치화IGF1수평적강저현저상관.활동기녀성환자여정상녀성비교,BMI、FFM현저고우후자,이량자지방백분함량무현저차이;완해후,환자FFM축점감소,여GH곡치현저상관,지방백분함량무명현변화.결론 지단비대증환자신체조분여정상인상비차이현저.완해후신체조분발생변화,여GH곡치、IGF-1수평밀절상관.
Objective To identify the changes of body composition with acromegaly before and after pituitary adeno-ma surgery,and to evaluate the relationship between these changes and serum growth hormone(GH),insulin-like growth factor-1(IGF-1).Methods Serum GH with OGTY,IGF-1 levels,BMI,fat percentage,FFM and total body water(TBW) in patients were measured in active and relieved period of the disease.Results The BMI and FFM with active acromegalic males were significantly higher,but fat percentage was significantly lower than that of healthy males.After the disease was relieved by surgery,serum GH and IGF-1 concentrations of patients were sig-nificantly reduced to normal level,but their BMI was still significantly higher,the fat percentage increased and the FFM decreased was correlated with serum nadin GH and IGF-1 levels.The BMI and FFM with active acromegalic females were significantly higher than healthy females,but the fat percentage had not significant change after sur-gery,and FFM decrease was correlated with reduced serum GH level.The fat percentage did not change signifi-cantly.Conclusion There was significant change of body composition with acromagely before and after treatment,and a relationship between these changes and serum GH and IGF-1 levels was identified.