中山大学学报(医学科学版)
中山大學學報(醫學科學版)
중산대학학보(의학과학판)
JOURNAL OF SUN YAT-SEN UNIVERSITY(MEDICAL SCIENCES)
2010年
2期
265-268,273
,共5页
向锦%符珈%卢佳斌%吴秋良
嚮錦%符珈%盧佳斌%吳鞦良
향금%부가%로가빈%오추량
鼻咽癌%肌上皮细胞癌%EB病毒
鼻嚥癌%肌上皮細胞癌%EB病毒
비인암%기상피세포암%EB병독
nasopharynx carcinoma%myoepithelial carcinoma%Epstein-Barr virus
[目的]分析鼻咽肌上皮细胞癌的临床及病理特征以及其与EB病毒的关系.[方法]对12例鼻咽肌上皮细胞癌进行临床、病理及随访观察,EBERS原位杂交及免疫组织化学标记.[结果]12例鼻咽肌上皮细胞癌患者中,男性患者7例,女性患者5例,男女比1.4:1;年龄24~65岁,中位年龄46岁.影像学资料都显示鼻咽部有明显的结节状肿物,肌上皮细胞的标记:S-100、SMA、P63、CK14及上皮标记:CK、CKL、CKH在12例肌上皮细胞癌中表达有差异,但是所有的肌上皮细胞癌恒定表达至少一项肌上皮细胞和上皮细胞标记.12例鼻咽肌上皮细胞癌EBERS原位杂交结果均为阴性.[讨论]肌上皮细胞癌是一种低度恶性的肿瘤,发生在鼻咽部极少见,其病理形态虽然复杂多变,但也有其特征性的形态特征,免疫组织化学及EBERS原位杂交有助于其诊断,在治疗上采用手术切除的基础上进行联合放射及化学治疗将有效地控制肿瘤的复发及转移.
[目的]分析鼻嚥肌上皮細胞癌的臨床及病理特徵以及其與EB病毒的關繫.[方法]對12例鼻嚥肌上皮細胞癌進行臨床、病理及隨訪觀察,EBERS原位雜交及免疫組織化學標記.[結果]12例鼻嚥肌上皮細胞癌患者中,男性患者7例,女性患者5例,男女比1.4:1;年齡24~65歲,中位年齡46歲.影像學資料都顯示鼻嚥部有明顯的結節狀腫物,肌上皮細胞的標記:S-100、SMA、P63、CK14及上皮標記:CK、CKL、CKH在12例肌上皮細胞癌中錶達有差異,但是所有的肌上皮細胞癌恆定錶達至少一項肌上皮細胞和上皮細胞標記.12例鼻嚥肌上皮細胞癌EBERS原位雜交結果均為陰性.[討論]肌上皮細胞癌是一種低度噁性的腫瘤,髮生在鼻嚥部極少見,其病理形態雖然複雜多變,但也有其特徵性的形態特徵,免疫組織化學及EBERS原位雜交有助于其診斷,在治療上採用手術切除的基礎上進行聯閤放射及化學治療將有效地控製腫瘤的複髮及轉移.
[목적]분석비인기상피세포암적림상급병리특정이급기여EB병독적관계.[방법]대12례비인기상피세포암진행림상、병리급수방관찰,EBERS원위잡교급면역조직화학표기.[결과]12례비인기상피세포암환자중,남성환자7례,녀성환자5례,남녀비1.4:1;년령24~65세,중위년령46세.영상학자료도현시비인부유명현적결절상종물,기상피세포적표기:S-100、SMA、P63、CK14급상피표기:CK、CKL、CKH재12례기상피세포암중표체유차이,단시소유적기상피세포암항정표체지소일항기상피세포화상피세포표기.12례비인기상피세포암EBERS원위잡교결과균위음성.[토론]기상피세포암시일충저도악성적종류,발생재비인부겁소견,기병리형태수연복잡다변,단야유기특정성적형태특정,면역조직화학급EBERS원위잡교유조우기진단,재치료상채용수술절제적기출상진행연합방사급화학치료장유효지공제종류적복발급전이.
[Objective]To analyze the clinical and pathological characteristics of myoepithelial carcinoma of nasopharynx,as well as its relationship with Epstein-Barr virus.[Methods]We report twelve cases of myoepithelial carcinoma of nasopharynx,study its clinical,histopathologic,and immunohistologic features,follow-up data and EBERS in-situ hybridization.[Results]Among age of patients ranged from 24 to 65 years(mean age=46 years).Imagery data demonstrated an extensive nodosity filling the nasopharynx,Of these 12 cgses,myoepithelial markers such as S-100,SMA,P63,CK14,CK5/6 and epithelial markers such as CK,CKL,CKH were not always all expressed at one case,but at less one of these two kind of markers expressed at one cage.The results of EBERS in-situ hybridization of 12 cases were negative.[Conclusion]Myoepithelial carcinoma is a low malignat tumor.It seldom takes place in nasopharynx,dispite its morphologic heterogeneity it has some special morphologic and immuohistologic characteristics as well as special result of EBERS in-situ hybridization,which may support its diagnosis.The combinde radiotherapy and chemotherapy after surgical removal of the tumor will control the recurrence and metabasis effectively.