CAJ | 학술논문

目的回顾性分析比较2型糖尿病患者骨折围手术期两种强化胰岛素治疗方案的疗效.方法将301例2型糖尿病合并骨折患者按胰岛素治疗方案分为Ⅰ、Ⅱ二组.Ⅰ组201例,三餐前30min皮下注射优泌林R和晚10:00皮下注射优泌林N;Ⅱ组100例,三餐前30 min皮下注射优泌林R、早餐前30 min和晚10:00皮下注射优泌林N.比较两组患者术前及术后血糖控制水平,探讨影响术前血糖达标时间的因素.结果术前血糖达标时间Ⅰ组(8.7±3.2)d,Ⅱ组(6.9±2.5)d(P＜o,01);Ⅱ组术后血糖控制更好;影响术前血糖达标时间的因素有:短效与中效胰岛素的比例、HbA1c和入院空腹血糖水平.结论在优泌林R三餐前注射的基础上加注优泌林N时,睡前与早餐前一日二次的疗法比单一睡前加注的疗法,对患者术前血糖达标更为有效.
목적 회고성분석비교2형당뇨병환자골절위수술기량충강화이도소치료방안적료효.방법 장301례2형당뇨병합병골절환자안이도소치료방안분위Ⅰ、Ⅱ이조.Ⅰ조201례,삼찬전30min피하주사우비림R화만10:00피하주사우비림N;Ⅱ조100례,삼찬전30 min피하주사우비림R、조찬전30 min화만10:00피하주사우비림N.비교량조환자술전급술후혈당공제수평,탐토영향술전혈당체표시간적인소.결과 술전혈당체표시간Ⅰ조(8.7±3.2)d,Ⅱ조(6.9±2.5)d(P＜o,01);Ⅱ조술후혈당공제경호;영향술전혈당체표시간적인소유:단효여중효이도소적비례、HbA1c화입원공복혈당수평.결론 재우비림R삼찬전주사적기출상가주우비림N시,수전여조찬전일일이차적요법비단일수전가주적요법,대환자술전혈당체표경위유효.
Objective We retrospectively compare the therapeutic effect between two subcutaneous insulin regimens in type 2 diabetes mellitus (T2DM) patients with the fractures during the perioperative period. Methods The 301 patients with T2DM plus fractures were divided into two groups: groups I (n=201) receiving regular insulin three times a day before meals+NPH insulin at bedtime and group Ⅱ (n=100) receiving regular insulin three times a day+NPH insulin twice daily. The difference in glucose target arrival time and associated factors were analyzed, and glucose control levels were observed. Results The average time achieving satisfactory BG level was (8.7± 3.2)days and (6.9± 2.5)days for group Ⅰand Ⅱ respectively(P<0.01). Binary logistics regression showed that the time of achieving BG level was associated with fasting glucose(FPG), HbA1c and the proportion of the regular insulin and the NPH insulin. Conclusions The results indicate that insulin injection five times a day can shorten the time of achieving desired BG level. The time of achieving satisfactory BG level is associated with fasting glucose level, HbA1c and the ratio of the dose of regular insulin and NPH.