中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
17期
2590-2591
,共2页
孙志芳%胡延良%范春霞%蔡翠霞%王纪秋
孫誌芳%鬍延良%範春霞%蔡翠霞%王紀鞦
손지방%호연량%범춘하%채취하%왕기추
体层摄影术,X线计算机%正电子发射型%后程加速放疗%肺肿瘤
體層攝影術,X線計算機%正電子髮射型%後程加速放療%肺腫瘤
체층섭영술,X선계산궤%정전자발사형%후정가속방료%폐종류
Tomography,X-ray%Positron emission%Late-course accelerated fractionated radiotherapy%Lung carcinoma
目的 探讨PET/CT定位对后程加速超分割三维适形放射治疗Ⅲ期肺鳞癌患者疗效的影响.方法 将79例行放射治疗的Ⅲ期肺鳞癌患者,根据病灶定位方式的不同将所有患者分为PET/CT组(PET/CT定位)37例和普通CT组(普通CT定位)42例,前2/3疗程结果常规超分割三维适形放射治疗治疗(40Gy左右),后1/3采用加速超分割三维适形放射治疗(1.5Gy左右,2次/d)；两组患者均采用相同的化疗方案辅助治疗.全疗程1个月左右.观察两组临床疗效和治疗过程中出现的各种不良反应等.结果 PET/CT组和普通CT组总缓解率分别为73.0％和71.4％(x2=1.347,P＞0.05)；两组患者发生的放射损伤主要包括肺和气管损伤,急性期两组的发生率分别为56.8％和57.1％,差异无统计学意义(x2=2.178,P＞0.05),晚期普通CT组放射损伤的发生率为69.0％,显著高于PET/CT组62.2％(x2=4.142,P＜0.05).随访1年PET/CT组患者肺门和纵隔淋巴结复发率为43.7％,显著低于普通CT组的59.4％(x2=4.732,P＜0.05).结论 PET/CT定位对后程加速超分割三维适形放射治疗Ⅲ期肺鳞癌患者可以减少晚期肺和气管损伤,降低肺门 和纵隔淋巴结复发率.
目的 探討PET/CT定位對後程加速超分割三維適形放射治療Ⅲ期肺鱗癌患者療效的影響.方法 將79例行放射治療的Ⅲ期肺鱗癌患者,根據病竈定位方式的不同將所有患者分為PET/CT組(PET/CT定位)37例和普通CT組(普通CT定位)42例,前2/3療程結果常規超分割三維適形放射治療治療(40Gy左右),後1/3採用加速超分割三維適形放射治療(1.5Gy左右,2次/d)；兩組患者均採用相同的化療方案輔助治療.全療程1箇月左右.觀察兩組臨床療效和治療過程中齣現的各種不良反應等.結果 PET/CT組和普通CT組總緩解率分彆為73.0％和71.4％(x2=1.347,P＞0.05)；兩組患者髮生的放射損傷主要包括肺和氣管損傷,急性期兩組的髮生率分彆為56.8％和57.1％,差異無統計學意義(x2=2.178,P＞0.05),晚期普通CT組放射損傷的髮生率為69.0％,顯著高于PET/CT組62.2％(x2=4.142,P＜0.05).隨訪1年PET/CT組患者肺門和縱隔淋巴結複髮率為43.7％,顯著低于普通CT組的59.4％(x2=4.732,P＜0.05).結論 PET/CT定位對後程加速超分割三維適形放射治療Ⅲ期肺鱗癌患者可以減少晚期肺和氣管損傷,降低肺門 和縱隔淋巴結複髮率.
목적 탐토PET/CT정위대후정가속초분할삼유괄형방사치료Ⅲ기폐린암환자료효적영향.방법 장79례행방사치료적Ⅲ기폐린암환자,근거병조정위방식적불동장소유환자분위PET/CT조(PET/CT정위)37례화보통CT조(보통CT정위)42례,전2/3료정결과상규초분할삼유괄형방사치료치료(40Gy좌우),후1/3채용가속초분할삼유괄형방사치료(1.5Gy좌우,2차/d)；량조환자균채용상동적화료방안보조치료.전료정1개월좌우.관찰량조림상료효화치료과정중출현적각충불량반응등.결과 PET/CT조화보통CT조총완해솔분별위73.0％화71.4％(x2=1.347,P＞0.05)；량조환자발생적방사손상주요포괄폐화기관손상,급성기량조적발생솔분별위56.8％화57.1％,차이무통계학의의(x2=2.178,P＞0.05),만기보통CT조방사손상적발생솔위69.0％,현저고우PET/CT조62.2％(x2=4.142,P＜0.05).수방1년PET/CT조환자폐문화종격림파결복발솔위43.7％,현저저우보통CT조적59.4％(x2=4.732,P＜0.05).결론 PET/CT정위대후정가속초분할삼유괄형방사치료Ⅲ기폐린암환자가이감소만기폐화기관손상,강저폐문 화종격림파결복발솔.
Objective To investigate the irfluence of PET/CT positioning on the effect of late-course accelerated hyperfractionated and three-dimensional conformal radiotherapy for stage Ⅲ lung squamous cell carcinoma.Methods 79 stage Ⅲ lung squarnous cell carcinoma patients were enrolled and divided into PET/CT group(n =37 cases,PET/CT positioning) and general CT group (n =42 cases,general CT positioning) according to the way of positioning.The conventional fractionated 3 DCRT( about 40 Gy) was used in previous 2/3 time and hyperfractionated( about 1.5 Gy) was used in later 1/3 time.Both groups used chemotherapy as adjuvant therapy.Full course of the treatment was a month or so.And the clinical efficacy and a variety of adverse reactions of the two groups was observed.Results The total rate of remission in PET/CT group were 73.0％,and 71.4％ in general CT group,and there was no significant difference in the two groups (x2 =1.347,P ＞ 0.05 ).The major radiation injury were radioactive pulmonary injury and tracheal damage,incidence rates were 56.8％and 57.1％ in acute stage,and there was no significant difference in the two groups( x2 =2.178,P ＞ 0.05 ) ; but in late stage 69.0％ in general CT group was significantly higher than 62.2％ in PET/CT group(x2 =4.142,P ＜0.05).Ater followed-up 1 year,the recurrence rate of hillar and mediastinal lymph node in PET/CT group was 43.7％,lower than that of the general CT group( 59.4％ ) ( x2 =4.732,P ＜ 0.05 ).Conclusion PET/CT positioning in late-course accelerated hyperfractionated and three-dimensional conformal radiotherapy for stage Ⅲ lung squamous cell carcinoma could reduce late stage radioactive pulmonary injury and tracheal damage,lower the recurrence rate of hillar and mediastinal lymph node.
