中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2012年
4期
320-323
,共4页
欧阳天斌%唐世雄%张立涛%姚寿国%张旭群%陆徐%陈星
歐暘天斌%唐世雄%張立濤%姚壽國%張旭群%陸徐%陳星
구양천빈%당세웅%장립도%요수국%장욱군%륙서%진성
氢离子浓度%胃食管反流%诊断
氫離子濃度%胃食管反流%診斷
경리자농도%위식관반류%진단
Hydrogen-ion concentration%Gastroesophageal reflux%Diagnosis
目的 探讨24 h双探针pH检测在咽喉反流疾病(laryngopharyngeal reflux disease,LPR)诊治中的临床意义.方法 依据pH检测24 h内食管上端反流事件次数超过6.9次为基线将难治性咽喉炎患者分为LPR组和对照组各17例,并给予咽喉炎常规治疗+抑酸治疗.分析pH检测与反流症状指数(The reflux symptom index,RSI)量表和反流检查(The reflux finding score,RFs)评分的一致性,比较两组治疗前后RSI、RFS的变化情况.结果 LPR组坐立位反流次数中位数(10.0)明显高于平卧位(3.0),两者差异有统计学意义(Z=-3.62,P＜0.01),而对照组两者差异无统计学意义(Z=-0.60,P＞0.05).pH检测判断LPR阳性结果与RSI量表、RSI量表+RFS评分的判断结果差异无统计学意义(P＞0.05),Kappa检验有统计学意义(k值分别为0.47和0.53,p值均＜0.01).治疗后LPR组与对照组的RS(l)、RFS均有不同程度下降,但LPR组的下降幅度明显高于对照组,差异均有统计学意义(t值分别为3.74、3.01,P值均＜(0.01).结论 pH检测是LPR临床抗酸治疗的重要依据.
目的 探討24 h雙探針pH檢測在嚥喉反流疾病(laryngopharyngeal reflux disease,LPR)診治中的臨床意義.方法 依據pH檢測24 h內食管上耑反流事件次數超過6.9次為基線將難治性嚥喉炎患者分為LPR組和對照組各17例,併給予嚥喉炎常規治療+抑痠治療.分析pH檢測與反流癥狀指數(The reflux symptom index,RSI)量錶和反流檢查(The reflux finding score,RFs)評分的一緻性,比較兩組治療前後RSI、RFS的變化情況.結果 LPR組坐立位反流次數中位數(10.0)明顯高于平臥位(3.0),兩者差異有統計學意義(Z=-3.62,P＜0.01),而對照組兩者差異無統計學意義(Z=-0.60,P＞0.05).pH檢測判斷LPR暘性結果與RSI量錶、RSI量錶+RFS評分的判斷結果差異無統計學意義(P＞0.05),Kappa檢驗有統計學意義(k值分彆為0.47和0.53,p值均＜0.01).治療後LPR組與對照組的RS(l)、RFS均有不同程度下降,但LPR組的下降幅度明顯高于對照組,差異均有統計學意義(t值分彆為3.74、3.01,P值均＜(0.01).結論 pH檢測是LPR臨床抗痠治療的重要依據.
목적 탐토24 h쌍탐침pH검측재인후반류질병(laryngopharyngeal reflux disease,LPR)진치중적림상의의.방법 의거pH검측24 h내식관상단반류사건차수초과6.9차위기선장난치성인후염환자분위LPR조화대조조각17례,병급여인후염상규치료+억산치료.분석pH검측여반류증상지수(The reflux symptom index,RSI)량표화반류검사(The reflux finding score,RFs)평분적일치성,비교량조치료전후RSI、RFS적변화정황.결과 LPR조좌립위반류차수중위수(10.0)명현고우평와위(3.0),량자차이유통계학의의(Z=-3.62,P＜0.01),이대조조량자차이무통계학의의(Z=-0.60,P＞0.05).pH검측판단LPR양성결과여RSI량표、RSI량표+RFS평분적판단결과차이무통계학의의(P＞0.05),Kappa검험유통계학의의(k치분별위0.47화0.53,p치균＜0.01).치료후LPR조여대조조적RS(l)、RFS균유불동정도하강,단LPR조적하강폭도명현고우대조조,차이균유통계학의의(t치분별위3.74、3.01,P치균＜(0.01).결론 pH검측시LPR림상항산치료적중요의거.
Objective To determine the clinical value of 24 h double-probe pH-mctry for the diagnosis and treatment of laryngopharyngeal reflux (LPR).Methods According to the pH-metry resuhs (whether the reflux events record in the upper esophagus is more than 6.9), patients of refractory pharyngolaryngitis were divided into LPR and control groups (each of 17 cases).All patients treated with anti-acid therapy and conventional pharyngo-laryngitis therapy.Correlation between pH-metry and the reflux symptom index (RSI),the reflux symptom index (RFI) were analyzed.Changes of the RSI and RFI in different group were calculated in post-treatment.Results In the LPR group,the median reflux events of the upright time were higher than the supine time ( Z =- 3.62,P ＜ 0.01 ),but the difference was not discovered in the control group(Z =-0.60,P ＞ 0.05 ).There were no statistical difference between RSI,RSI and RFS with pH-metry,and with moderate concordance ( κ were 0.47,0.53,P ＜ 0.01,respectively).Compared to pre-treatment, the RSI and RFI were decreased both in LPR group and contorl group,Amplitude decreased in LPR group significantly higher than the contorl groups,with statistical difference( t were 3.74,3.01,P ＜ 0.01,respectively).Conclusion The 24 h double-probe pH-metry is significant for the anti-acid therapy of LPR.
